RSS 1.0Clinical Medicine (Theses and Dissertations)
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Macrophage immunometabolism in the host response to Mycobacterium tuberculosis infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Tuberculosis (TB) is the leading infectious disease killer in the world, alongside HIV. Our understanding of the complex host immune response to Mycobacterium tuberculosis (Mtb) remains incomplete, but varied clinical ... -
An investigation of epigenetic effects in Atherosclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Epigenetic mechanisms may explain some of the missing heritability associated with CVD and how external factors such as diet, environment and lifestyle contribute to disease development and progression. This thesis aimed ... -
Effects of bile acids and fatty acids on cell signalling in human colorectal cancer cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Colorectal cancer is a multifactorial disease. The interplay between genetic and environmental factors leads to the development of CRC. There have been great advancements in the knowledge of genetic alterations leading to ... -
Novel mediators regulating innate and adaptive type 17 immune responses
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)The discovery of a third subset of T helper cells and more recently innate T cell subsets which preferentially express IL-17A has led to intensive investigation into the roles these cells play in both host defence and ... -
Adaption of the Functional Lumen Imaging Probe for non-radiological evaluation of the upper oesophageal sphincter
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)The aim of this research was to adapt the Functional Lumen Imaging Probe (FLIP), a novel non-radiological measurement tool, to measure upper oesophageal sphincter (DOS) distensibility and opening patterns during swallowing. ...
