Recent Submissions

  • Examining the breadth and burden of chronic kidney disease in community-dwelling older adults 

    Canney, Mark (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
    Introduction: Chronic kidney disease (CKD), characterised by reductions in glomerular filtration rate (GFR), is associated with premature mortality and end stage kidney disease. Older adults have the highest prevalence of ...
  • The role of monocytes in ANCA associated vascultis 

    O'BRIEN, EÓIN (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
    ANCA associated vasculitis (AAV) encompasses several autoimmune conditions characterised by destruction of small vessels, inflammation of the respiratory tract, and glomerulonephritis. Most patients harbour autoantibodies ...
  • Vaccination as a means of disease prevention in HIV infected individuals; successes, challenges & opportunities 

    Bergin, Colm (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
    This thesis is structured to systemically assess susceptibility to vaccine preventable infections in HIV-infected adults, to investigate effectiveness of an integrated vaccine programme as a model of care for vaccine ...
  • Evaluation of neuroimaging biomarkers in amyotrophic lateral sclerosis 

    SCHUSTER, CHRISTINA (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition characterised by relentless upper and lower motor neuron degeneration. The clinical spectrum, symptoms onset, genetic vulnerability and ...
  • Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease 

    TIGHE, DONAL (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
    Loss of response (LOR) to anti-TNFa therapy is a significant problem, and leads to increased hospitalisation rates, surgical intervention, and steroid dependency. Loss of response is multifactorial. However there ...

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