Recent Submissions

  • Vaccination as a means of disease prevention in HIV infected individuals; successes, challenges & opportunities 

    Bergin, Colm (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
    This thesis is structured to systemically assess susceptibility to vaccine preventable infections in HIV-infected adults, to investigate effectiveness of an integrated vaccine programme as a model of care for vaccine ...
  • Evaluation of neuroimaging biomarkers in amyotrophic lateral sclerosis 

    SCHUSTER, CHRISTINA (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition characterised by relentless upper and lower motor neuron degeneration. The clinical spectrum, symptoms onset, genetic vulnerability and ...
  • Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease 

    TIGHE, DONAL (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
    Loss of response (LOR) to anti-TNFa therapy is a significant problem, and leads to increased hospitalisation rates, surgical intervention, and steroid dependency. Loss of response is multifactorial. However there ...
  • Macrophage immunometabolism in the host response to Mycobacterium tuberculosis infection 

    GLEESON, LAURA ELIZABETH (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
    Tuberculosis (TB) is the leading infectious disease killer in the world, alongside HIV. Our understanding of the complex host immune response to Mycobacterium tuberculosis (Mtb) remains incomplete, but varied clinical ...
  • An investigation of epigenetic effects in Atherosclerosis 

    Byrne, Mikaela (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)
    Epigenetic mechanisms may explain some of the missing heritability associated with CVD and how external factors such as diet, environment and lifestyle contribute to disease development and progression. This thesis aimed ...

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