Browsing by Subject "Clinical Medicine, Ph.D."
Now showing items 1-20 of 95
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A Langevin equation approach to diffusion magnetic resonance imaging
(Trinity College. Institute of Neuroscience, 2010)Diffusion-weighted magnetic resonance imaging (DW MRI) is a noninvasive technique which is sensitive to the translational motion of water molecules because of their Brownian motion, allowing us to probe the microstructure ... -
A novel protein NFKBIL-1 regulates the activity of key transcription factors
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Inflammation is a physiological process initiated in response to an injury or infection. Proper execution of the inflammatory response requires activation of several pro- inflammatory transcription factors. Nuclear Factor ... -
A promising hypoxia-inducible suicide gene therapy strategy for prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Gene therapy targeted to hypoxic tumour cells may allow selective killing of malignant cells. The induction of gene expression under hypoxic conditions is governed by the activation of hypoxia-inducible factor 1 and its ... -
A study of food consumption patterns of children and adults in Ireland : implications for the development of food-based dietary guidelines
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Food-based dietary guidelines (FBDG) are guidelines derived from nutrient targets which are translated into food-based guidelines so they can be adopted by the general population. In order for FBDG to be successful, they ... -
A study of postprandial lipoprotein metabolism and glycaemic control in a population with type 2 diabetes mellitus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Postprandial hypertriglyceridaemia predicts cardiovascular disease and is a characteristic of both obesity and poorly controlled diabetes. To address the relative impact of improved glycaemic control and weight loss on ... -
Adaption of the Functional Lumen Imaging Probe for non-radiological evaluation of the upper oesophageal sphincter
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)The aim of this research was to adapt the Functional Lumen Imaging Probe (FLIP), a novel non-radiological measurement tool, to measure upper oesophageal sphincter (DOS) distensibility and opening patterns during swallowing. ... -
An extensive evaluation of the validity of reported energy intakes in the North/South Ireland food consumption survey
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)The North/South Ireland Food Consumption Survey (NSIFCS) was conducted between 1997 and 1999, on a representative sample of 1379 adults from the Republic of Ireland and Northern Ireland, aged 18 to 64 years. Food intakes ... -
Application of probabilistic modelling to food chemical exposure assessments
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Risk assessment of food chemical intake is at the core of food safety policy within the EU and the assessment of food chemical exposure is an integral part of the risk assessment process. There is an increasing demand to ... -
Aspects of muscle performance, mobility limitations, excercise interventions and cognitive functioning in older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)In section A, two studies were conducted to systematically investigate and compare the cross sectional and longitudinal physiological determinants of the age-related loss of lower extremity muscle power in healthy and ... -
Barrett's oesophagus and associated cancer : the influence of bile acid regulated genetic factors and intestinal transcription factors in the pathogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Gastrooesophageal reflux disease (GORD) is very common and it is estimated that up to 20% of the western population will experience weekly heartburn. The initial simple mucosal damage can lead to further complications like ... -
Bile acids and Barrett's oesophagus : the development of a functional siRNA screen to identify novel therapeutic targets
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The development of oesophageal adenocarcinoma (OAC) occurs in a setting of chronic reflux known as gastro-oesophageal reflux disease (GORD) and with a recognised premalignant lesion, Barrett’s oesophagus (BO). BO is ... -
Biomechanical measures of function of the ano-rectal region of the human body
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)In this research, the Functional Lumen Imaging Probe (FLIP), a novel measurement tool, was adapted to measure the biomechanical properties and morphological changes of the ano-rectal region during distension and provocative ... -
Bolus-tracking arterial spin labeling : a new approach to quantifying cerebral perfusion with magnetic resonance imaging
(TCIN (Trinity College Institute of Neuroscience) Scholarly Publications, 2009)The body of work presented herein describes the development a new technique for the quantification of cerebral perfusion, termed bolus-tracking arterial spin labeling (btASL). The technique uses a novel non-compartmental ... -
C5L2, a nonsignalling C5A receptor is uncoupled to G proteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The complement anaphylatoxins are prominent mediators of host defence and inflammation. The small subunit of the fifth component of complement, C5a has complex effects in vivo including potential anti- and pro-inflammatory ... -
Cardiovascular risk in non-diabetes mellitus insulin resistant states
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)This thesis explores the various cardiovascular risks that occur in insulin resistant states apart from type 2 diabetes mellitus (T2DM). Various cardiovascular risk markers and metabolic derangements related to cardiovascular ... -
Characterisation of nanoparticle distribution, intergrity and toxicity in vivo and in vitro using advanced spectroscopic and microscopic approaches
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Much uncertainty surrounds the potential toxicity of new engineered nanomaterials to human health and the environment, either during manufacture, use or at the end of their life cycle. The current generalised methodologies ... -
Characterisation of the redox protein Thioredoxin from the gastric pathogen Helicobacter pylori
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Gastric colonisation by the Gram-negative bacterium Helicobacter pylori is the primary cause of peptic ulceration, type B chronic gastritis, gastric adenocarcinoma, and is linked to the progression of gastric MALT lymphoma. ... -
Characterization of proteins associated with the LFA-1 mediated cytoskeletal / signaling complex in locomotory T lymphocytes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)LFA-1 plays a crucial role in all aspects of T cell locomotion in both immune physiological functions and pathological conditions. T cell locomotion is associated with translocation of protein kinase C isoenzymes β and δ ... -
Clinical, metabolic and biochemical responses to a diet and aerobic excercise intervention in early-onset type 2 diabetes mellitus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)This study was a longitudinal, randomised, controlled trial. Two primary groups of subjects were recruited for comparison: young obese patients (less than 30 years of age) with early- onset type 2 diabetes (YT2), and a ... -
Cytokine expression in coronary artery disease : high sensitivity detection in a patient cohort and analysis of its effect on cardiac myoblast cells in an in vitro model
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Cardiovascular disease has evolved into one of the major causes of death in the developed world. Common clinical presentations of the disease are Acute Coronary Syndromes (ACS), Heart Failure, Carotid disease, Abdominal ...