Greasing the path to BAX/BAK activation
Citation:
Hollville, E., Martin, S.J., Greasing the path to BAX/BAK activation, Cell, 148, 5, 2012, 845-846Download Item:
1-s2.0-S0092867412001638-main.pdf (PDF) 172.6Kb
Abstract:
BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the threshold for apoptosis-associated cytochrome c release. Association of mitochondria with other cellular membrane compartments is required for BAK/BAX exposure to these sphingolipids.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
Author's Homepage:
http://people.tcd.ie/martinsjDescription:
PUBLISHED
Author: MARTIN, SEAMUS
Type of material:
Journal ArticleCollections:
Series/Report no:
Cell148
5
Availability:
Full text availableKeywords:
BAX/BAKSubject (TCD):
Immunology, Inflammation & InfectionDOI:
http://dx.doi.org/10.1016/j.cell.2012.02.006Licences: