Recent Submissions

  • Insufficient Evidence for "Autism-Specific" Genes 

    Mitchell, Kevin; Challman, Thomas D.; Bernier, Raphael; Bourgeron, Thomas; Chung, Wendy K.; Constantino, John N.; Eichler, Evan E.; Jacquemont, Sebastien; Miller, David T.; Zoghbi, Huda Y.; Martin, Christa Lese; Ledbetter, David H. (2020)
    Despite evidence that deleterious variants in the same genes are implicated across multiple neurodevelopmental and neuropsychiatric disorders, there has been considerable interest in identifying genes that, when mutated, ...
  • Getting a gRIP on Flu by Casting the DAI 

    MARTIN, SEAMUS; Clancy, Danielle M. (2016)
  • De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences 

    Mc Lysaght, Aoife (2020)
    Recent evidence demonstrates that novel protein-coding genes can arise de novo from non- genic loci. This evolutionary innovation is thought to be facilitated by the pervasive translation of non-genic transcripts, which ...
  • Faster Evolving Primate Genes Are More Likely to Duplicate 

    Mc Lysaght, Aoife; O'Toole, Áine N.; Hurst, Laurence D. (2018)
    An attractive and long-standing hypothesis regarding the evolution of genes after duplication posits that the duplication event creates new evolutionary possibilities by releasing a copy of the gene from constraint. Apparent ...
  • IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment 

    Campbell, Matthew; Augustine, Josy; Pavlou, Sofia; Ali, Imran; Harkin, Kevin; Ozaki, Ema; Stitt, Alan W.; Xu, Heping; Chen, Mei (2019)
    Background: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health ...

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