Browsing by Author "MARTIN, SEAMUS"
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Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You.
MARTIN, SEAMUS (2013)Autophagy, a process for recycling cellular constituents, is normally associated with cell survival and is thought to be beneficial for tumor maintenance. However, in this issue of Cancer Cell, Lamy and colleagues report ... -
Autosis: A new addition to the cell death tower of babel
MARTIN, SEAMUS (2014)Autophagy is a cellular recycling and stress response that degrades organelles and long-lived proteins and serves to protect cells from the potential damage induced by dysfunc- tional organelles and protein aggregates. ... -
Bcl-2 family proteins participate in mitochondrial quality control by regulating parkin/PINK1-dependent mitophagy
MARTIN, SEAMUS (2014)Mitophagy facilitates the selective elimination of impaired or depolarized mitochondria through targeting the latter to autophagosomes. Parkin becomes localized to depolarized mitochondria in a PINK1-dependent manner and ... -
Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival.
MARTIN, SEAMUS; CREAGH, EMMA (2009)Members of the caspase family of cysteine proteases coordinate cell death through restricted proteolysis of diverse protein substrates and play a conserved role in apoptosis from nematodes to man. However, while numerous ... -
CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.
CREAGH, EMMA; MARTIN, SEAMUS (2001)Proteins possessing the caspase recruitment domain (CARD) motif have been implicated in pathways leading to activation of caspases or NF-kappaB in the context of apoptosis or inflammation, respectively. Here we report the ... -
Caspase-1 promiscuity is counterbalanced by rapid inactivation of the processed enzyme.
MARTIN, SEAMUS; LOGUE, SUSAN; WALSH, JOHN GERARD (2011)Members of the caspase family of cysteine proteases coordinate the highly disparate processes of apoptosis and inflammation. However, while hundreds of substrates for the apoptosis effector caspases (caspase-3 and caspase-7) ... -
Diverse Activators of the NLRP3 Inflammasome Promote IL-1ß Secretion by Triggering Necrosis
MARTIN, SEAMUS (2015)The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing “signal I” and diverse agents such as ATP, Nigericin, ... -
Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis.
MARTIN, SEAMUS (2009)Summary Bcl-2 family proteins regulate apoptosis by controlling the release of mitochondrial cytochrome c via the Bax/Bak channel. However, recent studies have also implicated several members of this family in the regulation ... -
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
MARTIN, SEAMUS (2014)Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to ... -
Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.
MARTIN, SEAMUS (2001)Members of the caspase family of cysteine proteases play central roles in coordinating the stereotypical events that occur during apoptosis. Because the major executioner caspases, caspase-3 and caspase-7, exhibit almost ... -
Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing
MARTIN, SEAMUS; LAVELLE, EDWARD (2018) -
The FEBS Journal: Passing the editorial baton
MARTIN, SEAMUS (2014) -
Getting a gRIP on Flu by Casting the DAI
MARTIN, SEAMUS; Clancy, Danielle M. (2016) -
Glucose deprivation induces ATF4-mediated apoptosis through TRAIL death receptors
MARTIN, SEAMUS (2017) -
Granzyme B-dependent proteolysis acts as a switch to enhance the pro-inflammatory activity of IL-1
LAVELLE, EDWARD; MARTIN, SEAMUS (2011)Granzyme B is a cytotoxic lymphocyte-derived protease that plays a central role in promoting apoptosis of virus-infected target cells, through direct proteolysis and activation of constituents of the cell death machinery. ... -
Greasing the path to BAX/BAK activation
MARTIN, SEAMUS (2012)BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the ... -
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.
MARTIN, SEAMUS (2009)Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its mechanisms constitutes a formidable ... -
Identification of small-molecule elastase inhibitors as antagonists of IL-36 cytokine activation
MARTIN, SEAMUS (2018) -
Inhibitor of Apoptosis Proteins (IAPs) and Their Antagonists Regulate Spontaneous and Tumor Necrosis Factor (TNF)-induced Proinflammatory Cytokine and Chemokine Production.
LAVELLE, EDWARD; MARTIN, SEAMUS (2013)Inhibitor of apoptosis proteins (IAPs) play a major role in determining whether cells undergo apoptosis in response to TNF as well as other stimuli. However, TNF is also highly proinflammatory through its ability to trigger ... -
Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation
MARTIN, SEAMUS; CREAGH, EMMA (2004)Caspases coordinate the internal demolition of the cell that is seen during apoptosis. Proteolytic processing of caspases is observed during apoptosis, and this correlates with conversion of inactive caspase proenzymes ...