Bacterial L-forms on tap: an improved methodology to generate Bacillus subtilis L-forms heralds a new era of research
Citation:
Kevin M. Devine, Bacterial L-forms on tap: an improved methodology to generate Bacillus subtilis L-forms heralds a new era of research, Molecular Microbiology, 83, 1, 2012, 10 13Download Item:
Abstract:
Bacterial L-forms are cell wall-less forms of bacteria that usually grow with a conventional cell wall. Despite being important for research, L-forms are difficult to generate reproducibly and research in this area is challenging. The manuscript published in this issue by Dominguez-Cuevas and colleagues reports a method to rapidly, quantitatively and reproducibly generate populations of L-forms in Bacillus subtilis. Importantly, the methodology may be applicable to other bacteria heralding a new era of L-form research. Moreover, the genetic requirements of this method provide insights into how Lipid II synthesis and autolysin expression/activity are normally balanced and the central role of the WalRK two-component system in this process.
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Science Foundation Ireland (SFI)
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http://people.tcd.ie/kdevineDescription:
PUBLISHED
Author: DEVINE, KEVIN
Type of material:
Journal ArticleCollections
Series/Report no:
Molecular Microbiology83
1
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Full text availableKeywords:
Immunology, Infection, Bacillus subtilisSubject (TCD):
Immunology, Inflammation & InfectionMetadata
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