Browsing by Subject "Immunology"
Now showing items 1-20 of 136
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Activation of human invariant natural killer T cells with a thioglycoside analogue of ?-galactosylceramide
(2011)Activation of CD1d-restricted invariant NKT (iNKT) cells with the glycolipid ?-galactosylceramide (?-GalCer) confers protection against disease in murine models, however, clinical trials in humans have had limited impact. ... -
The activation of unconventional T cells by Staphylococcus aureus
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Staphylococcus aureus is a major human pathogen of multiple tissue sites. The emergence of antibiotic-resistant strains promises greater morbidity in the future. No S. aureus vaccine has so far succeeded in translating ... -
Alterations in cytochrome-c oxidase expression between praziquantel-resistant and susceptible strains of Schistosoma mansoni.
(1998)The genetic differences between praziquantel-resistant (R) and susceptible (S) strains of Schistosoma mansoni (Fallon & Doenhoff, 1994) were explored using RAPD and by cloning differentially expressed mRNAs by subtractive ... -
Analysis of dynamic tyrosine phosphoproteome in LFA-1 triggered migrating T-cells.
(2011)The ordered, directional migration of T-lymphocytes is a key process during immune surveillance and response. This requires cell adhesion to the high endothelial venules or to the extracellular matrix by a series of surface ... -
Analysis of the role of Krebs cycle rewiring in macrophage cytokine production
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)A striking change has happened in the field of immunology whereby specific metabolic processes have been shown to be a critical determinant of immune cell activation. Multiple immune receptor types rewire metabolic pathways ... -
Ascaris and ascariasis
(2011)Ascaris lumbricoides and Ascaris suum are widespread parasitic nematodes of humans and pigs respectively. Recent prevalence data suggests that approximately 1.2 billion people are infected. Adult worms exhibit an overdispersed ... -
Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain
(2011)Abstract: Background: Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial ... -
Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions in IFN- ? receptor or immunoglobulin Y chain genes
(The Rockefeller University Press, 1997)Using a murine respiratory challenge model we have previously demonstrated a role for Th1 cells in natural immunity against Bordetella pertussis, but could not rule out a role for antibody. Here we have demonstrated that ... -
Autophagy and cytokines
(2011)Autophagy is a highly conserved homoeostatic mechanism for the lysosomal degradation of cytosolic constituents, including long-lived macromolecules, organelles and intracellular pathogens. Autophagosomes are formed in ... -
Autophagy controls IL-1? secretion by targeting pro-IL-1? for degradation
(2011)Autophagy is a key regulator of cellular homeostasis that can be activated by pathogen-associated molecules and recently has been shown to influence IL-1? secretion by macrophages. However, the mechanisms behind this are ... -
Bacterial L-forms on tap: an improved methodology to generate Bacillus subtilis L-forms heralds a new era of research
(2012)Bacterial L-forms are cell wall-less forms of bacteria that usually grow with a conventional cell wall. Despite being important for research, L-forms are difficult to generate reproducibly and research in this area is ... -
Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells
(2011)T follicular helper (TFH) cells are critical initiators in the development of T cell-dependent humoral immunity and the generation of protective immunity. We demonstrate that TFH cell accumulation and Ab production are ... -
Candidate role for TLR3 L412F in disease progression in Idiopathic Pulmonary Fibrosis (IPF) during bacterial and viral infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)In this thesis, we investigated the mechanisms by which TLR3 Leu412Phe (L412F) promotes disease progression in idiopathic pulmonary fibrosis (IPF) patients. IPF is a fatal interstitial lung disease of unknown aetiology and ... -
Caspase-1 promiscuity is counterbalanced by rapid inactivation of the processed enzyme.
(2011)Members of the caspase family of cysteine proteases coordinate the highly disparate processes of apoptosis and inflammation. However, while hundreds of substrates for the apoptosis effector caspases (caspase-3 and caspase-7) ... -
Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man
(The American Society for Biochemistry and Molecular Biology, 2004)The caspase family of cysteine proteases plays a conserved role in the coordinate demolition of cellular structures during programmed cell death from nematodes to man. Because cells undergoing programmed cell death in ... -
CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis.
(2009)Despite the fact that CD4+CD25+Foxp3+ regulatory T cells (Treg cells) play a central role in maintaining self-tolerance and that IL-17-producing CD4+ T cells (Th17 cells) are pathogenic in many autoimmune diseases, ... -
CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment response in chronic hepatitis C virus infection.
(Elsevier, 2010)BACKGROUND & AIMS: Increasing age is associated with impaired immune function and in chronic HCV infection specifically, with progressive fibrosis, liver failure, HCC and impaired responses to antiviral therapy. T-lymphocyte ... -
Characterisation of innate immune responses in children with Down syndrome
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2020)Introduction: Down syndrome (DS) is associated with increased incidence of infections in childhood, higher mortality from sepsis, and other inflammatory conditions such as arthropathy, thyroid and coeliac disease. Several ...