Synthesis and evaluation of phosphoramidate and phosphorothioamidate analogues of amiprophos methyl as potential antimalarial agents
Citation:
Christine Mara, Enda Dempsey, Angus Bell, James W. Barlow, Synthesis and evaluation of phosphoramidate and phosphorothioamidate analogues of amiprophos methyl as potential antimalarial agents, Bioorganic & Medicinal Chemistry Letters, 21, 20, 2011, 6180 - 6183Download Item:
Synthesis and evaluation of phosphoramidate and phosphorothioamidate analogues of amiprophos methyl as potential antimalarial agents.pdf (Published (author's copy) - Peer Reviewed) 319.4Kb
Abstract:
A series of phosphoramidate and phosphorothioamidate compounds based on the lead antitubulin herbicidal agents amiprophos methyl (APM) and butamifos were synthesised and evaluated for antimalarial activity. Of these compounds, phosphorothioamidates were more active than their oxo congeners and the nature of both aryl and amido substituents influenced the desired activity. The most active compound was 46, O-ethyl-O-(2-methyl-4-nitrophenyl)-N-cyclopentyl phosphorothioamidate, which was more effective than the lead compound.
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Enterprise Ireland
PC/2005/070
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http://people.tcd.ie/abellhttp://people.tcd.ie/dempseen
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PUBLISHED
Author: BELL, ANGUS; DEMPSEY, ENDA
Publisher:
ElsevierType of material:
Journal ArticleCollections:
Series/Report no:
Bioorganic & Medicinal Chemistry Letters;21;
20;
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Full text availableKeywords:
Immunology, phosphoramidateLicences: