Browsing by Author "BELL, ANGUS"
Now showing items 1-18 of 18
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Anti-disease therapy for malaria: 'resistance proof'?
BOEHM, DANIELA; BELL, ANGUS (2013)Antimalarial drugs have in the past fallen prey to resistance and this problem is likely to continue in the future. One approach to developing drugs that might be less prone to resistance might be to target the disease ... -
Antimalarial drug discovery and design in the Era of resistance
BELL, ANGUS (2013)These are interesting times for antimalarial drug research. On the one hand, recent reports from Southeast Asia paint a grim picture of reduced malarial parasite susceptibility to artemisinin combination therapies ... -
Antimalarial peptides: the long and the short of it
BELL, ANGUS (2011)Antimicrobial peptides include a diverse array of both natural and synthetic molecules varying greatly in size, charge, hydrophobicity and secondary-structural features. Although better known as antibacterial agents, many ... -
Antimitotic herbicides bind to an unidentifed site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites.
BELL, ANGUS; DEMPSEY, ENDA (2013)Malarial parasites are exquisitely susceptible to a number of microtubule inhibitors but most of these compounds also affect human microtubules. Herbicides of the dinitroaniline and phosphorothioamidate classes however ... -
Design and evaluation of antimalarial peptides derived from prediction of short linear motifs in proteins related to erythrocyte invasion
BELL, ANGUS (2015)The purpose of this study was to investigate the blood stage of the malaria causing parasite, Plasmodium falciparum, to predict potential protein interactions between the parasite merozoite and the host erythrocyte and ... -
A family of cyclophilin-like molecular chaperones in Plasmodium falciparum
MARIN MENENDEZ, ALEJANDRO; BELL, ANGUS (2012)The cyclophilins are a large family of proteins implicated in folding, transport and regulation of other proteins and are potential drug targets in cancer and in some viral and parasitic infections. The functionality of ... -
Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A and derivatives
BELL, ANGUS; MARIN MENENDEZ, ALEJANDRO (BioMed Central, 2010)Cyclophilins are distributed widely among different organisms and are proposed drug targets for a number of diseases including HIV and hepatitis C infection and ischemia. Cyclophilins play roles in folding and chaperoning ... -
Identification of Plasmepsin Inhibitors as Selective Antimalarial Agents using Ligand Based Drug Design
DEMPSEY, ENDA; LLOYD, DAVID G; CARTA, GIORGIO; FAYNE, DARREN; BELL, ANGUS (Elsevier, 2011)We describe the application of Ligand Based Virtual Screening technologies towards the discovery of novel Plasmepsin (PM) inhibitors, a family of malarial parasitic aspartyl proteases. Pharmacophore queries were used to ... -
Immunophilin-protein interactions in Plasmodium falciparum.
BELL, ANGUS; BELL, ANGUS (2015)Immunophilins comprise two protein families, cyclophilins (CYPs) and FK506-binding proteins (FKBPs), and are the major receptors for the immunosuppressive drugs cyclosporin A (CsA) and FK506 (tacrolimus), respectively. ... -
Overexpression, purification and assessment of cyclosporin binding of a family of cyclophilins and cyclophilin-like proteins of the human malarial parasite Plasmodium falciparum
BELL, ANGUS; MARIN MENENDEZ, ALEJANDRO (2011)Malaria represents a global health, economic and social burden of enormous magnitude. Chemotherapy is at the moment a largely effective weapon against the disease, but the appearance of drug-resistant parasites is reducing ... -
PEST sequences in the malaria parasite Plasmodium falciparum: a genomic study
BELL, ANGUS (BioMed Central, 2003)Anopheles gambiae is the main vector of Plasmodium falciparum in Africa. The mosquito midgut constitutes a barrier that the parasite must cross if it is to develop and be transmitted. Despite the central role of the mosquito ... -
Synthesis and evaluation of phenoxyoxazaphospholidine, phenoxyoxazaphosphinane, and benzodioxaphosphininamine sulfides and related compounds as potential anti-malarial agents
BELL, ANGUS; DEMPSEY, ENDA (2013)A series of phenoxyoxazaphospholidine, phenoxyoxazaphosphinane and benzodioxaphosphininamine sulfides and related cyclic organophosphorus compounds based on the lead anti-tubulin herbicides amiprophos methyl and butamifos ... -
Synthesis and evaluation of phosphoramidate and phosphorothioamidate analogues of amiprophos methyl as potential antimalarial agents
BELL, ANGUS; DEMPSEY, ENDA (Elsevier, 2011)A series of phosphoramidate and phosphorothioamidate compounds based on the lead antitubulin herbicidal agents amiprophos methyl (APM) and butamifos were synthesised and evaluated for antimalarial activity. Of these ... -
Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution
BELL, ANGUS (2015)Antimalarial chemotherapy continues to be challenging in view of the emergence of drug resistance, especially artemisinin resistance in Southeast Asia. It is critical that we identify novel anti-malarial drugs that inhibit ...