Conjugated Quantum Dots Inhibit the Amyloid β (1-42) Fibrillation Process
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2011Citation:
Thakur G., Micic M., Yang Y., Li W., Movia D., Giordani S., Zhang H. and Leblanc R., Conjugated Quantum Dots Inhibit the Amyloid β (1-42) Fibrillation Process, International Journal of Alzheimer's Disease, 2011, 2011, 502386Download Item:
Conjugated Quantum Dots Inhibit the Amyloid ? (1?42) Fibrillation Process.pdf (Published (publisher's copy) - Peer Reviewed) 5.824Mb
Abstract:
Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstarted that the amyloid beta mixed with and conjugated to dihydrolipoic acid (DHLA)-capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process. Transmission
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electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloid ? (1-42) (A? (1-42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs.
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Science Foundation Ireland (SFI)
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http://people.tcd.ie/giordanshttp://people.tcd.ie/hozhang
http://people.tcd.ie/dmovia
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International Journal of Alzheimer's Disease2011
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Particles and fields physics, NanoparticlesSubject (TCD):
Nanoscience & Materials , NeuroscienceDOI:
http://dx.doi.org/10.4061/2011/502386Licences: