dc.contributor.author | GIORDANI, SILVIA | en |
dc.contributor.author | ZHANG, HONGZHOU | en |
dc.contributor.author | MOVIA, DANIA | en |
dc.date.accessioned | 2011-04-15T15:49:54Z | |
dc.date.available | 2011-04-15T15:49:54Z | |
dc.date.issued | 2011 | en |
dc.date.submitted | 2011 | en |
dc.identifier.citation | Thakur G., Micic M., Yang Y., Li W., Movia D., Giordani S., Zhang H. and Leblanc R., Conjugated Quantum Dots Inhibit the Amyloid β (1-42) Fibrillation Process, International Journal of Alzheimer's Disease, 2011, 2011, 502386 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/54847 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstarted that the amyloid beta mixed with and conjugated to dihydrolipoic acid (DHLA)-capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process. Transmission
2
electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloid ? (1-42) (A? (1-42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs. | en |
dc.description.sponsorship | This work is supported by the Scientific Award Committee (SAC)-Pilot Study Award (Miller School of Medicine, University of Miami) and Science Foundation Ireland (PIYRA). | en |
dc.format.extent | 502386 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | International Journal of Alzheimer's Disease | en |
dc.relation.ispartofseries | 2011 | en |
dc.rights | Y | en |
dc.subject | Particles and fields physics | en |
dc.subject | Nanoparticles | en |
dc.title | Conjugated Quantum Dots Inhibit the Amyloid β (1-42) Fibrillation Process | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/giordans | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/hozhang | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/dmovia | en |
dc.identifier.rssinternalid | 71356 | en |
dc.identifier.doi | http://dx.doi.org/10.4061/2011/502386 | en |
dc.subject.TCDTheme | Nanoscience & Materials | en |
dc.subject.TCDTheme | Neuroscience | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |