Recent advances in regulatory T cell therapy of autoimmunity, graft rejection and cancer
Citation:
Dunne PJ, Fletcher JM, Recent advances in regulatory T cell therapy of autoimmunity, graft rejection and cancer, Recent Patents in Inflammation Allergy Drug Discovery, 4, 3, 2010, 231 - 243Download Item:
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Abstract:
Since their initial discover in the 1970s and their subsequent resurgence in the mid 1990s, regulatory
T (Treg) cells have become one of the most studied cell subsets. Treg cells prevent autoimmunity and
limit aggressive immune responses directed against either pathogen or foreign antigen that might
serve to damage host tissue. In contrast, tumour cells have been shown to recruit and/or induce Treg
cells, which can impair tumour immunity. The immunoregulatory function of these cells makes them
ideal therapeutic candidates for the treatment of autoimmune disease and in the prevention of
transplant rejection. Likewise, depletion of Treg cells remains an additional option in the treatment of
cancer. Despite significant advances in the treatment of murine models of disease with Treg cells, it
has been difficult to transfer this success into the clinic. In this review we will discuss relevant patents
and the most recent advances in the use of Treg cells to treat autoimmunity, prevent graft rejection as
well as the use of anti-bodies to deplete these cells in cancer.
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http://people.tcd.ie/fletchjhttp://people.tcd.ie/dunnep5
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PUBLISHEDPMID: 20812898
Author: Dunne, Padraig; Fletcher, Jean
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Recent Patents in Inflammation Allergy Drug Discovery4
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Full text availableKeywords:
Immunology, Regulatory T cells (Treg)Subject (TCD):
Immunology, Inflammation & InfectionLicences: