Browsing by Author "Fletcher, Jean"
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Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis.
Fletcher, Jean; Fearon, Ursula (2018)Rheumatoid arthritis is characterized by synovial proliferation, neovascularization and leucocyte extravasation leading to joint destruction and functional disability. The blood vessels in the inflamed synovium are highly ... -
Differential regulation of human Treg and Th17 cells by fatty acid synthesis and glycolysis
Phelan, Andreea; Fletcher, Jean; Moran, Barry (2019)In this study we examined the metabolic requirements of human T helper cells and the effect of manipulating metabolic pathways in Th17 and Treg cells. The Th17:Treg cell axis is dysregulated in a number of autoimmune or ... -
Enriched CD141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis.
Fletcher, Jean; Fearon, Ursula; Moran, Barry; Canavan, Mary (2018)CD141+ DC are implicated in antiviral and antitumor immunity. However, mechanisticstudies in autoimmune disease are limited. This is the first study to our knowledgeexamining CD141+ DC in autoimmune disease, specifically ... -
Enrichment of inflammatory IL-17 and TNF-α secreting CD4+ T cells within colorectal tumours despite the presence of elevated CD39+ T regulatory cells and increased expression of the immune checkpoint molecule, PD-1.
Fletcher, Jean (2016)T cell infiltration into colorectal tumors has been shown to correlate with improved patient outcomes. However, more detailed information on the makeup and relationships between the infiltrating T cell subsets is lacking. ... -
Immune regulation by interferon-beta in multiple sclerosis
Sweeney, Cheryl (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Interferon (IFN)-β is a commonly used therapy for patients with relapsing remitting multiple sclerosis (RRMS). Although IFN-β has been shown to exert various immunomodulatory effects, the therapeutic mechanisms are still ... -
Increased expression of Tbet in CD4+ T cells from clinically isolated syndrome patients at high risk of conversion to clinically definite MS.
Fletcher, Jean (2016)Background: The ability to identify clinically isolated syndrome (CIS) patients at high risk of progression to clinically definite multiple sclerosis (CDMS) would be clinically beneficial. The initiation of T cell ... -
Plant-derived polyphenols modulate human dendritic cell metabolism and immune function via AMPK-dependent induction of heme oxygenase-1
Fletcher, Jean; Dunne, Aisling (2019-03-01)Polyphenols are important immunonutrients which have been investigated in the context of inflammatory and autoimmune disease due to their significant immunosuppressive properties. However, the mechanism of action of many ... -
Recent advances in regulatory T cell therapy of autoimmunity, graft rejection and cancer
Dunne, Padraig; Fletcher, Jean (2010)Since their initial discover in the 1970s and their subsequent resurgence in the mid 1990s, regulatory T (Treg) cells have become one of the most studied cell subsets. Treg cells prevent autoimmunity and limit aggressive ... -
Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation
Dunne, Aisling; Fletcher, Jean; Creagh, Emma; Basdeo, Sharee (2016)The main limitation to successful transplantation is the antigraft response developed by the recipient immune system, and the adverse side effects of immunosuppressive agents which are associated with significant toxicity ... -
T cells in multiple sclerosis and experimental autoimmune encephalomyelitis
Fletcher, Jean; Mills, Kingston; Lalor, Stephen (2010)Multiple sclerosis (MS) is a demyelinating inflammatory disorder of the central nervous system (CNS), which involves autoimmune responses to myelin antigens. Studies in experimental autoimmune encephalomyelitis (EAE), ... -
The pathogenicity and regulation of CD161⁺Th17 lineage cells in rheumatoid arthritis
Basdeo, Sharee Ann (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Pathogenic Th17 cells, which produce their signature cytokine IL-17, play a key role in autoimmune diseases such as rheumatoid arthritis (RA) and therefore, have been the target of recently developed therapeutics. On the ... -
The role of metabolism, hypoxia and immunomodulatory therapy in regulating the human Treg:Th17 cell axis
Cluxton, Deborah (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Th17 cells are important pathogenic effector cells in autoimmune diseases such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). On the other hand, regulatory T (Treg) cells play a crucial role in ...