RSS 1.0Biochemistry (Scholarly Publications)
Browse by
Recent Submissions
-
In silico analysis of the human milk oligosaccharide glycome reveals key enzymes of their biosynthesis.
(2022)Human milk oligosaccharides (HMOs) form the third most abundant component of human milk and are known to convey several benefits to the neonate, including protection from viral and bacterial pathogens, training of the ... -
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signalling
(2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ... -
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
(2022)To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH ... -
Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages
(2022)Activated macrophages undergo metabolic reprogramming, which not only supports their energetic demands but also allows for the production of specific metabolites that function as signaling molecules. Several Krebs cycles, ... -
The role of itaconate in host defense and inflammation
(2022)Macrophages exposed to inflammatory stimuli including LPS undergo metabolic reprogramming to facilitate macrophage effector function. This metabolic reprogramming supports phagocytic function, cytokine release, and ROS ...
