Browsing Pharmacology & Therapeutics by Date of Publication
Now showing items 1-20 of 84
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Local modulation of pulmonary vascular function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2000)The aim of the present study was to investigate the role of endothelial smooth muscle interaction in the local modulation of pulmonary vascular function. The main part of the work was carried out in isolated rings of porcine ... -
Stress and long-term potentiation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2001)Stress is a physiological reaction which the body copes with by a variety of mechanisms in order to restore homeostasis. Amongst these is an increase in plasma glucocorticoids, catecholamines and increases in brain ... -
A study of the impact of highly active antiretroviral therapy on the pharmacoepidemiology and pharmacoeconomics of HIV infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2001)The HIV pandemic has resulted in the most intense and as yet unparalleled effort devoted to antimicrobial drug development ever to be initiated in the developed world. The intensive drug research and development, compressed ... -
Risk markers for acute stroke in Ireland - association of sodium-lithium countertransport (SLC) with vascular disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)The work in this thesis is divided into two parts, an epidemiological study of the risk markers for stroke in an Irish population and a laboratory study of the possible association between sodium lithium countertransport ... -
Regulation of expression of transcription factors nuclear factor-kappa B and early growth response-1 by Helicobacter pylori
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)The Gram-negative bacterium Helicobacter pylori colonizes the human gastric epithelium and is a causative agent of peptic ulcer disease and gastric adenocarcinoma. Although H. pylori colonization is associated with gastric ... -
Endogenous acetylcholine modulates synaptic plasticity in the hippocampus in vivo
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)Long-term potentiation (LTP) provides a model for the synaptic mechanisms underlying learning and memory. Acetylcholine (ACh) is an important excitatory transmitter in the hippocampus, and cholinergic activity is essential ... -
Arterial pulse in health and disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)Arterial stiffness exerts a major influence on cardiac afterload and coronary perfusion. Indices of arterial stiffness have therefore been proposed as surrogate markers of cardiovascular risk and as a potential therapeutic ... -
Pharmacoeconomics of Statin Therapy in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)Cardiovascular disease is the leading cause of death in most industrialised countries, including Ireland. Cholesterol lowering by pharmacological intervention prevents atherosclerotic plaque progression and has been shown ... -
Prescribing for institutionalised older people
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)Introduction: In order to investigate aspects of prescribing practice and drug administration in institutionalised older people, the following aims for the study were developed; -- To compare prescribing practices between ... -
The use of the General Medical Services prescription database for pharmacoepidemiological studies in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)Pharmacoepidemiology may be divided into three main subdivisions, namely pharmacovigilence, drug utilisation and prescribing quality. An aim of this thesis was to demonstrate the usefulness of the General Medical Services ... -
Adherence to antihypertensive medication in the United Arab Emirates : patient and doctor perspectives
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)Approximately half of the patients taking medication for hypertension have problems following the prescribed regime to the extent that they do not derive optimal clinical benefit. Prior to this study, there was little data ... -
Synaptic plasticity in animal models of stress : serotonergic mechanisms
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2005)The inhibitory effect of acute elevated platform stress exposure on synaptic plasticity in the CA1 region of the hippocampus in vivo was investigated. Such stress exposure was confirmed to inhibit subsequent long term ... -
A study of antioxidant protection in fluoride induced rat kidney lysosomal damage
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2005)Fluoride as an inorganic chemical species is ubiquitous in our environment. Fluorosis is a disease or state of chronic poisoning from long-term exposure to excessive quantities of inorganic compounds of fluorine and is a ... -
Modelling compliance with antihypertensives and statins in Ireland, using a national prescription claims database
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)Hypertension and high cholesterol, especially in the middle-aged and elderly, are fairly common, and pharmacological therapy is often required to control them. In spite of substantial knowledge of the consequences of ... -
Neurotransmitter interactions in the control of spatial memory and exploratory activity in the rat
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)The role of the central cholinergic system in learning and memory is well established, with many investigations reporting that central cholinergic hypofunction is correlated with impaired performance on various behavioural ... -
Structural remodelling of the vascular wall in relation to ageing and arterial stiffening
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)Structural remodelling of the vascular wall has been investigated in this study in terms of ageing and the process of vascular stiffening. While common structural adaptations are often presumed for ageing and vascular ... -
Pharmaceutical pricing and reimbursement : an Irish perspective
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)There has been a five-fold increase in state expenditure on medicines under the Community Drug Schemes in Ireland over the last decade (1994 to 2004). As a result of this marked increase in pharmaceutical expenditure, the ... -
Comparing primary prevention with secondary prevention to explain decreasing coronary heart disease death rates in Ireland 1985 - 2000
(2007)BACKGROUND: To investigate whether primary prevention might be more favourable than secondary prevention (risk factor reduction in patients with coronary heart disease(CHD)). METHODS: The cell-based IMPACT CHD mortality ... -
Pharmacologically induced long-term enhancement in the hippocampus in vivo
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2007)The present study investigated the mechanisms underlying a pharmacologically induced long-term enhancement (LTE) of fast excitatory synaptic transmission in the CA1 region of the rat hippocampus in vivo. The role of ... -
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
(2008)Alzheimer?s disease (AD) constitutes a rising threat to public health. Despite extensive research in cellular and animal models, identifying the pathogenic agent present in the human brain and showing that it confers key ...
