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  Health Technology Assessment of CD19 CAR T-Cell Therapies in the Irish Healthcare Setting. 

  Carey, Niamh Aisling (Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2022)

  The aim of this research was to undertake health technology assessments of CD19 CAR T-cell therapies, tisagenlecleucel and axicabtagene ciloleucel. A bespoke cost-utility model was developed to examine the cost effectiveness ...
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  Role of Protein Phosphatase 2A inhibition in modulation of VE-cadherin and Claudin-5 in human brain microvascular endothelial cells and the potential reversal by small molecule activators of PP2A (SMAPs) 

  Konieczna, Sylwia Natalia (Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2021)

  Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase which plays a key role in modulating signalling, metabolism and cell growth, and is implicated in various pathologies. There is conflicting evidence regarding ...
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  Cost Effectiveness of PCSK9 Inhibitors for the Secondary Prevention of Cardiovascular Disease in Ireland: Considerations given to Population Heterogeneity 

  O DONNELL, HELEN GERALDINE (Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2020)

  The aim of this thesis was to evaluate the cost-effectiveness of PCSK9 inhibitors (alirocumab and evolocumab for the secondary prevention of CVD (cardiovascular disease) in Ireland. Also, to identify the subgroups of this ...
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  Cost Effectiveness of Treatment Strategies for Skin Cancer in the Irish Healthcare Setting 

  GORRY, CLAIRE MARIE (Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2020)

  The incidence of both non-melanoma skin cancer (NMSC) and melanoma skin cancer are increasing in Ireland and are associated with significant healthcare costs. Cost-effectiveness analysis (CEA) can assist in resource ...
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  Aß Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus 

  Rowan, Michael; O'Riordan, Kenneth J.; Hu, Neng-Wei (2018)

  Promotion of long-term depression (LTD) mechanisms by synaptotoxic soluble oligomers of amyloid-β (Aß) has been proposed to underlie synaptic dysfunction in Alzheimer’s disease (AD). Previously, LTD was induced by relatively ...

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