Browsing Biochemistry (Scholarly Publications) by Sponsor "Science Foundation Ireland (SFI)"
Now showing items 1-20 of 146
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Absence of Mitochondrial Uncoupling Protein 1 Affects Apoptosis in Thymocytes, Thymocyte/T-Cell profile and Peripheral T-Cell Number
(Elsevier, 2010)Our laboratory has previously demonstrated the presence of constitutively expressed mitochondrial uncoupling protein 1 in mouse thymocytes. In our endeavours to understand the role of mitochondrial uncoupling protein 1 in ... -
Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice
(2011)Mitochondrial uncoupling protein 3 (UCP3) is consituitively expressed in mitochondria from thymus and spleen of mice, and confocal microscopy has been used to visualize UCP3 in situ in mouse thymocytes. UCP3 is present ... -
Activation of biliverdin-IXα reductase by inorganic phosphate and related anions
(2007)The effect of pH on the initial-rate kinetic behaviour of BVR-A (biliverdin-IX? reductase) exhibits an alkaline optimum with NADPH as cofactor, but a neutral optimum with NADH as cofactor. This has been described as dual ... -
Activation of host pattern recognition receptors by viruses
(2010)Viral recognition by the host innate immune system has become an exciting and growing area of research focus in recent years. It is now apparent that multiple pattern recognition receptor (PRR) families, including Toll-like ... -
Activation of human invariant natural killer T cells with a thioglycoside analogue of ?-galactosylceramide
(2011)Activation of CD1d-restricted invariant NKT (iNKT) cells with the glycolipid ?-galactosylceramide (?-GalCer) confers protection against disease in murine models, however, clinical trials in humans have had limited impact. ... -
Activation of mixed glia by A-beta-specific Th1 and Th17 cells and its regulation by Th2 cells
(2010)Microglia are innate immune cells of the CNS, that act as antigen-presenting cells (APC) for antigen-specific T cells and respond to inflammatory stimuli, such as amyloid-beta (A?), resulting in the release of neurotoxic ... -
Advances in immunotherapy for the treatment of glioblastoma.
(2017)Glioblastoma (GBM) is an aggressive brain tumour, associated with extremely poor prognosis and although there have been therapeutic advances, treatment options remain limited. This review focuses on the use of immunotherapy, ... -
Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential.
(2015)Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis. Altered activity of caspases, particularly caspase-1, has ... -
Autophagy and inflammatory diseases.
(2013)Autophagy is a cellular mechanism for the sequestration and degradation of intracellular pathogens and compromised organelles, particularly damaged mitochondria. Autophagy also clears other cellular components, such as ... -
Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells
(2013)The immune system has evolved regulatory mechanisms to control immune responses to self-antigens. Regulatory T (Treg) cells play a pivotal role in maintaining immune tolerance, but tumour growth is associated with local ... -
Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.
(2014)Adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis. The toxin targets CD11b-expressing phagocytes and delivers into their cytosol an adenylyl cyclase (AC) enzyme that ... -
Building unique bonds to fight misplaced DNA
(2013)A cyclic dinucleotide comprised of GMP and AMP was previously shown to be a key intermediate during activation of innate immune responses to cytosolic DNA. A report by Patel and Tuschl groups published in Cell reveals the ... -
Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis
(2019)Murine inflammatory caspase-11 has an important role in intestinal epithelial inflammation and barrier function. Activation of the non-canonical inflammasome, mediated by caspase-11, serves as a regulatory pathway for the ... -
CD4 TRMcells following infection and immunization: Implications for more effective vaccine design
(2018)The induction of immunological memory, which is mediated by memory T and B cells, is central to adaptive protective immunity to pathogens induced by previous infection and is the cornerstone of effective vaccine design. ... -
Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.
(2015)The circadian clock allows an organism to anticipate daily changes imposed by the environment. The response to LPS is altered depending on time of day; however, the molecular mechanisms underlying this are unclear. We find ... -
Cloning, expression, purification, crystallization and preliminary X-ray diffraction of a lysine-specific permease from Pseudomonas aeruginosa
(2014)The prokaryotic lysine-specific permease (LysP) belongs to the amino acid– polyamine–organocation (APC) transporter superfamily. In the cell, members of this family are responsible for the uptake and recycling of nutrients, ... -
Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target
(2019)Staphylococcus aureus expresses a number of cell wall-anchored proteins that mediate adhesion and invasion of host cells and tissues and promote immune evasion, consequently contributing to the virulence of this organism. ... -
Competition for nutrients; an emerging role in controlling immune responses
(2019)Changes in cellular metabolism are associated with the activation of diverse immune subsets. These changes are fuelled by nutrients including glucose, amino acids and fatty acids, and are closely linked to immune cell fate ... -
A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes
(2015)The lipid cubic phase or in meso method is a robust approach for crystallizing membrane proteins for structure determination. The uptake of the method is such that it is experiencing what can only be described ... -
Congruence of tissue expression profiles from Gene Expression Atlas, SAGEmap and TissueInfo databases.
(2003)Background: Extracting biological knowledge from large amounts of gene expression information deposited in public databases is a major challenge of the postgenomic era. Additional insights may be derived by data integration ...