Activation of host pattern recognition receptors by viruses
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Journal ArticleDate:
2010Access:
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Carty, M., Bowie, A.G, Activation of host pattern recognition receptors by viruses, Clinical and Experimental Immunology, 161, 3, 2010, 397-406Download Item:
BrennanBowie author version.pdf (Published (author's copy) - Peer Reviewed) 234.0Kb
Abstract:
Viral recognition by the host innate immune system has become an exciting and growing
area of research focus in recent years. It is now apparent that multiple pattern recognition
receptor (PRR) families, including Toll-like receptors (TLRs), RIG-I-like receptors (RLRs) and
NOD-like receptors (NLRs), contribute significantly to viral detection by sensing viral proteins
and nucleic acids, leading to induction of cytokines and type I interferons (IFNs). Of
particular current interest is the sensing of viral DNA within infected cells, since the PRRs
responsible for this are only partially defined. Recently RNA polymerase III (Pol III) was
shown to transcribe some viral DNAs into RNA for detection by RIG-I, leading to IFN
induction. Another novel mechanism of viral DNA recognition unveiled, leading to
proinflammatory cytokine production, involves the PYHIN family member AIM2.
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Grant Number
Science Foundation Ireland (SFI)
Author's Homepage:
http://people.tcd.ie/agbowiehttp://people.tcd.ie/cartymi
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PUBLISHED
Author: Bowie, Andrew; Carty, Michael
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Clinical and Experimental Immunology161
3
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Full text availableKeywords:
immune systemSubject (TCD):
Immunology, Inflammation & InfectionDOI:
http://dx.doi.org/10.1111/j.1365-2249.2010.04196.xLicences: