Browsing Medical Gerontology (Scholarly Publications) by Sponsor "Science Foundation Ireland (SFI)"
Now showing items 1-20 of 72
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Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA)
(2021)Objective: To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged ... -
Alluvial visualization and computation of probabilities of transitions in frailty index states over an 8-year period using multi-state Markov models
(2021)The Frailty Index (FI) is an operationalization of frailty in older adults based on the accumulation of health deficits. FI cut-offs define the non-frail, prefrail and frail states. We described longitudinal transitions ... -
Angiotensin-Converting Enzyme (ACE) genetic variation and longevity in Peruvian older people: a cross-sectional study
(2020)Background: Some studies have suggested that the insertion(I)/deletion(D) polymorphism of the Angiotensin-Converting Enzyme (ACE) gene may be associated with human longevity, especially in centenarians. However, this ... -
Approximate entropies of resting state continuous neurocardiovascular physiological signals are associated with physical frailty in older adults
(2021)Frailty in older adults is characterised by dysregulation in multiple physiological systems. The frailty phenotype is defined on the basis of exhaustion, unexplained weight loss, weakness, slowness and low physical activity ... -
Associations between Cardiovascular Signal Entropy and Cognitive Performance over Eight Years
(2021)In this study, the relationship between non-invasively measured cardiovascular signal entropy and global cognitive performance was explored in a sample of community-dwelling older adults from The Irish Longitudinal Study ... -
Associations between neurocardiovascular signal entropy and physical frailty
(2021)In this cross-sectional study, the relationship between noninvasively measured neurocardiovascular signal entropy and physical frailty was explored in a sample of community-dwelling older adults from The Irish Longitudinal ... -
Biomarker Signatures of Two Phenotypical Pre-Frailty Types in The Irish Longitudinal Study on Ageing
(2022)Abstract: We investigated the biomarker signatures of two previously reported phenotypical prefrailty (PF) types in the first wave of The Irish Longitudinal Study on Ageing (TILDA): PF1 (unexplained weight loss and/or ... -
Blood Pressure Signal Entropy as a Novel Marker of Physical Frailty: Results from the FRAILMatics Clinical Cohort
(2022)In this study we investigated the association between information entropy in short length blood pressure signals and physical frailty status, in a group of patients aged 50+ recruited from the Falls and Syncope Unit at ... -
Building resilience and reversing frailty: a randomised controlled trial of a primary care intervention for older adults
(2023)Background: There is a need for effective primary care interventions that help older people combat frailty and build resilience. Objective: To study the effectiveness of an optimised exercise and dietary protein ... -
Cardiovascular signal entropy predicts all-cause mortality: evidence from The Irish Longitudinal Study on Ageing (TILDA)
(2022)In this study, the relationship between cardiovascular signal entropy and the risk of seven-year all-cause mortality was explored in a large sample of community-dwelling older adults from The Irish Longitudinal Study on ... -
Changes in Muscle Strength and Physical Function in Older Patients During and After Hospitalisation: a Prospective Repeated-Measures Cohort Study
(2020)Aim: To investigate changes in knee-extension strength and physical function in older adults during and after acute hospital admission, and the contributions of illness severity, frailty and sedentary activity to changes ... -
Characterising the Blood Pressure Response to Physical Counterpressure Manoeuvres Using Surface Electromyography in Adults with Long Covid
(2023)Objective: Orthostatic intolerance (OI) is common in Long Covid. Physical counterpressure manoeuvres (PCM) may improve OI in other disorders. We characterised the blood pressure-rising effect of PCM using surface ... -
Characterising the Blood Pressure Response to Physical Counterpressure Manoeuvres Using Surface Electromyography in Adults with Long Covid
(2023)Objective: Orthostatic intolerance (OI) is common in Long Covid. Physical counterpressure manoeuvres (PCM) may improve OI in other disorders. We characterised the blood pressure-rising effect of PCM using surface ... -
Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA)
(2020)Background: Cognitive and motor function in ageing are intertwined, but whether slower motor response time (MRT) to a cognitive stimulus could herald accelerated mobility decline is unknown. Using data from The Irish ... -
Clinical clustering of eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA)
(2020)Background: Orthostatic hypotension (OH) can be assessed with non-invasive continuous beat-to-beat haemodynamic monitoring during active stand (AS) testing; this yields large volumes of data outside the scope ... -
Clustering of behavioural symptoms and their associations with cognitive decline in older adults
(2020)Objectives: To examine (i) the clustering of reduced falls-efficacy, social withdrawal and physical activity withdrawal in Irish adults aged 50 years and older, and (ii) the concurrent and prospective associations of these ...