Blood Pressure Signal Entropy as a Novel Marker of Physical Frailty: Results from the FRAILMatics Clinical Cohort
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2022Access:
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Silvin P. Knight, Eoin Duggan and Roman Romero‐Ortuno, Blood Pressure Signal Entropy as a Novel Marker of Physical Frailty: Results from the FRAILMatics Clinical Cohort, Journal of Clinical Medicine, 2022Download Item:
Abstract:
In this study we investigated the association between information entropy in short length
blood pressure signals and physical frailty status, in a group of patients aged 50+ recruited from the
Falls and Syncope Unit at the Mercer’s Institute for Successful Ageing in St James’s Hospital, Dublin,
Ireland. This work is an external clinical validation of findings previously derived in a population‐
based cohort from The Irish Longitudinal Study on Ageing (TILDA). The hypothesis under investigation was that dysregulation (as quantified by entropy) in continuous non‐invasive blood pressure
signals could provide a clinically useful marker of physical frailty status. We found that in the 100
patients investigated, higher entropy in continuously measured resting state diastolic blood pressure was associated with worse physical frailty score, as measured by the Frailty Instrument for
primary care of the Survey of Health, Ageing and Retirement in Europe (SHARE‐FI). Since physical
frailty is defined as a pre‐disability state and hence it can be difficult for clinicians to identify at an
early stage, the quantification of entropy in short length cardiovascular signals could provide a clinically useful marker of the physiological dysregulations that underlie physical frailty, potentially
aiding in identifying individuals at higher risk of adverse health outcomes.
In this study we investigated the association between information entropy in short length
blood pressure signals and physical frailty status, in a group of patients aged 50+ recruited from the
Falls and Syncope Unit at the Mercer’s Institute for Successful Ageing in St James’s Hospital, Dublin,
Ireland. This work is an external clinical validation of findings previously derived in a population‐
based cohort from The Irish Longitudinal Study on Ageing (TILDA). The hypothesis under investi‐
gation was that dysregulation (as quantified by entropy) in continuous non‐invasive blood pressure
signals could provide a clinically useful marker of physical frailty status. We found that in the 100
patients investigated, higher entropy in continuously measured resting state diastolic blood pres‐
sure was associated with worse physical frailty score, as measured by the Frailty Instrument for
primary care of the Survey of Health, Ageing and Retirement in Europe (SHARE‐FI). Since physical
frailty is defined as a pre‐disability state and hence it can be difficult for clinicians to identify at an
early stage, the quantification of entropy in short length cardiovascular signals could provide a clinically useful marker of the physiological dysregulations that underlie physical frailty, potentially
aiding in identifying individuals at higher risk of adverse health outcomes.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
18/FRL/6188
Author's Homepage:
http://people.tcd.ie/romeroorhttp://people.tcd.ie/siknight
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PUBLISHED
Author: Romero-Ortuno, Roman; Knight, Silvin
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Journal ArticleSeries/Report no:
Journal of Clinical MedicineAvailability:
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Ageing , Digital Engagement , Next Generation Medical DevicesDOI:
https://doi.org/10.3390/jcm12010053Metadata
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