Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA)
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Chintapalli, R., Romero-Ortuno, R., Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA), Lancet EClinicalMedicine, 2020Download Item:
Abstract:
Background: Cognitive and motor function in ageing are intertwined, but whether slower motor response time (MRT) to a cognitive stimulus could herald accelerated mobility decline is unknown. Using data from The Irish Longitudinal Study on Ageing (TILDA), we examined whether slower MRT may predict a greater than expected increase in Time Up and Go (TUG) after 4 years. Methods: Participants aged 50 years or older were divided into two groups based on their mean MRT (<250 ms versus ≥ 250 ms). A repeated measures ANOVA compared TUG trajectories between groups, controlling for baseline age, sex, height, education level, mini mental-state examination (MMSE) score, self-reported vision and hearing, medical conditions (cardiovascular, cerebrovascular disease, diabetes), and number of medications. Findings: At Wave 1, 1982 (58.7%) had a mean MRT of <250 ms, with a mean TUG of 8.1 s (SD 1.6); and 1397 (41.3%) had an MRT of ≥ 250 ms, with a TUG of 9.0 s (SD 2.2). At Wave 3, TUG increased to 8.8 s (SD 2.0) and10.2 s (SD 3.9), respectively. The results of the adjusted repeated measures ANOVA suggested that there was a statistically significant interaction between MRT group and Wave (P= 0.023, h2p= 0.002). Interpretation:TILDA participants in the slower MRT group seemed to have faster mobility decline, but this effect was statistically and clinically small.
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Science Foundation Ireland (SFI)
18/FRL/6188
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http://people.tcd.ie/romeroorDescription:
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Author: Romero-Ortuno, Roman
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Lancet EClinicalMedicine;Availability:
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Choice reaction time, Time Up and Go, Cognition, Mobility, Longitudinal studySubject (TCD):
AgeingDOI:
https://doi.org/10.1016/j.eclinm.2020.100676Metadata
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