Associations between Cardiovascular Signal Entropy and Cognitive Performance over Eight Years
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Journal ArticleDate:
2021Access:
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Silvin P. Knight, Louise Newman, Siobhan Scarlett, John D. O?Connor, James Davis, Celine De Looze, Rose Anne Kenny, Roman Romero-Ortuno, Associations between Cardiovascular Signal Entropy and Cognitive Performance over Eight Years, Entropy, 2021Download Item:
Abstract:
In this study, the relationship between non-invasively measured cardiovascular signal
entropy and global cognitive performance was explored in a sample of community-dwelling older
adults from The Irish Longitudinal Study on Ageing (TILDA), both cross-sectionally at baseline
(n = 4525; mean (SD) age: 61.9 (8.4) years; 54.1% female) and longitudinally. We hypothesised that
signal disorder in the cardiovascular system, as quantified by short-length signal entropy during
rest, could provide a marker for cognitive function. Global cognitive function was assessed via Mini
Mental State Examination (MMSE) across five longitudinal waves (8 year period; n = 4316; mean
(SD) age: 61.9 (8.4) years; 54.4% female) and the Montreal Cognitive Assessment (MOCA) across
two longitudinal waves (4 year period; n = 3600; mean (SD) age: 61.7 (8.2) years; 54.1% female).
Blood pressure (BP) was continuously monitored during supine rest at baseline, and sample entropy
values were calculated for one-minute and five-minute sections of this data, both for time-series
data interpolated at 5 Hz and beat-to-beat data. Results revealed significant associations between BP
signal entropy and cognitive performance, both cross-sectionally and longitudinally. Results also
suggested that as regards associations with cognitive performance, the entropy analysis approach
used herein potentially outperformed more traditional cardiovascular measures such as resting heart
rate and heart rate variability. The quantification of entropy in short-length BP signals could provide
a clinically useful marker of the cardiovascular dysregulations that potentially underlie cognitive
decline.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
18/FRL/6188
Author's Homepage:
http://people.tcd.ie/romeroorhttp://people.tcd.ie/lonewman
http://people.tcd.ie/rkenny
http://people.tcd.ie/siknight
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PUBLISHEDOther Titles:
Age and AgeingAnnual and Scientific Meeting of the Irish Gerontological Society 2022: New Frontiers in Gerontology
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Journal ArticleSeries/Report no:
EntropyAvailability:
Full text availableKeywords:
Sample entropy, Cognition, Cognitive decline, Cardiovascular, Blood pressure, TILDASubject (TCD):
Ageing , Neuroscience , Next Generation Medical DevicesDOI:
https://doi.org/10.3390/e23101337Metadata
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