Structural, Photophysical, and Photobiological Studies on BODIPY-Anthracene Dyads
File Type:
PDFItem Type:
Journal ArticleDate:
2021Access:
openAccessCitation:
Callaghan, Susan, Vindstad, Benedikte E., Flanagan, Keith J., Melø, Thor B., Lindgren, Mikael, Grenstad, Kristin, Gederaas, Odrun A., Senge, Mathias, Structural, Photophysical, and Photobiological Studies on BODIPY-Anthracene Dyads, ChemPhotoChem, 2021Abstract:
We report the structural, photophysical, and
photobiological properties of a promising BODIPY-anthracene dyad
(BAD) that was previously shown to i nduce a therapeutic effect
against MDA-MB-468 cells. The BODIPY was synthesized and its
crystal structure was elucidated. We further investigate the potential
of this molecule as a versatile photosensitizer for photodynamic
therapy against AY27 and F98 cancer cell models. Both necrosis and
apoptosis were found to play a role in cell death and G1 phase
arrestation was observed following PDT. From time-resolved
spectroscopic analysis of absorbance and luminescence, it was found
that the singlet oxygen quantum yield of the most promising BODIPY anthracene dyad is high (>70%) and originates from a triplet state.
Interestingly, despite the efficient PDT effect, long-lived triplet states
or singlet oxygen formation were not observed when water (or D2O)
was used as the solvent but were readily observed in solvents such
as MeOH and EtOH.
Sponsor
Grant Number
Science Foundation Ireland
IvP 13/IA/1894
Author's Homepage:
http://people.tcd.ie/sengemType of material:
Journal ArticleCollections
Series/Report no:
ChemPhotoChem;Availability:
Full text availableDOI:
http://dx.doi.org/10.1002/cptc.202000191Metadata
Show full item recordLicences: