Self-assembled Ln(III) cyclen-based micelles and AuNPs conjugates as candidates for luminescent and magnetic resonance imaging (MRI) agents
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2020Author:
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Molloy, J. K., Nonat, A. M., O’Brien, J. E., Brougham, D. F., Gunnlaugsson, T., Self-assembled Ln(III) cyclen-based micelles and AuNPs conjugates as candidates for luminescent and magnetic resonance imaging (MRI) agents, Supramolecular Chemistry, 2020, 32, 6, 373-382Download Item:
Abstract:
The tetra-substituted heptadentate cyclen (1,4,7,10-tetraazacyclododecane) based Eu(III)/Tb(III)/Gd(III)-complexes 1.Ln and 2.Ln were developed. 1.Eu/Tb and 2.Eu/Tb were employed in the formation of luminescent self-assembling ternary structures, and we demonstrate that only in the presence of appropriate sensitizing antennae, was the lanthanide-emission of 1.Eu/Tb and 2.Eu/Tb ‘switched on’. 1.Gd/2.Gd were developed as potential MIR contrast agents, and employed in NMRD-measurements, where their relaxivity was investigated, and their (relatively high) r1 values determined. The formation of a self-assembled micelle-type structure was clearly observed for 2.Gd. The functionalised gold nanoparticles 1.Ln-AuNP were also synthesized from 1.Ln. As for the free complexes, the Ln-emission was ‘switched on’ for 1.Eu/Tb-AuNP in the presence of the antennae. NMRD measurements indicated that the relaxivity for the 1.Gd-AuNP systems was very high, with a value of 445 s-1mM-1 (at 400 MHz), demonstrating the cumulative effect of the relatively high number of 1.Gd complexes on the surface of the AuNP.
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Science Foundation Ireland
13/IA/1865
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http://people.tcd.ie/gunnlaut
Author: Gunnlaugsson, Thorfinnur
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Supramolecular Chemistry;32;
6;
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MIR contrast agents, Gold nanoparticles, Luminescence, Supramolecular chemistry, Lanthanides, Cyclen complexesDOI:
http://dx.doi.org/10.1080/10610278.2020.1742912Metadata
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