NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
Citation:
Tye, H., Yu, C.H., Simms, L.A., de Zoete, M.R., Kim, M.L., Zakrzewski, M., Penington, J.S., Harapas, C.R., Souza-Fonseca-Guimaraes, F., Wockner, L.F., Preaudet, A., Mielke, L.A., Wilcox, S.A., Ogura, Y., Corr, S.C., Kanojia, K., Kouremenos, K.A., De Souza, D.P., McConville, M.J., Flavell, R.A., Gerlic, M., Kile, B.T., Papenfuss, A.T., Putoczki, T.L., Radford-Smith, G.L., Masters, S.L., NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease, Nature Communications, 2018 Sep 13;9(1):3728Download Item:
Abstract:
Anti-microbial signaling pathways are normally triggered by innate immune receptors when detecting pathogenic microbes to provide protective immunity. Here we show that the inflammasome sensor Nlrp1 aggravates DSS-induced experimental mouse colitis by limiting beneficial, butyrate-producing Clostridiales in the gut. The colitis-protective effects of Nlrp1 deficiency are thus reversed by vancomycin treatment, but recapitulated with butyrate supplementation in wild-type mice. Moreover, an activating mutation in Nlrp1a increases IL-18 and IFNγ production, and decreases colonic butyrate to exacerbate colitis. We also show that, in patients with ulcerative colitis, increased NLRP1 in inflamed regions of the colon is associated with increased IFN-γ. In this context, NLRP1, IL-18 or IFN-γ expression negatively correlates with the abundance of Clostridiales in human rectal mucosal biopsies. Our data identify the NLRP1 inflammasome to be a key negative regulator of protective, butyrate-producing commensals, which therefore promotes inflammatory bowel disease.
Author's Homepage:
http://people.tcd.ie/corrscDescription:
PUBLISHED
Author: Corr, Sinead
Type of material:
Journal ArticleCollections
Series/Report no:
Nature communications;Availability:
Full text availableSubject (TCD):
Immunology, Inflammation & InfectionDOI:
https://doi-org.elib.tcd.ie/10.1038/s41467-018-06125-0Metadata
Show full item recordLicences: