dc.contributor.author | Egana, Mikel | en |
dc.date.accessioned | 2020-11-10T11:34:11Z | |
dc.date.available | 2020-11-10T11:34:11Z | |
dc.date.issued | 2021 | en |
dc.date.submitted | 2021 | en |
dc.identifier.citation | Gildea N, Rocha J, O'Shea D, Green S and Egaña M., Priming exercise accelerates pulmonary oxygen uptake kinetics during "work-to-work" cycle exercise in middle-aged individuals with type 2 diabetes, European Journal of Applied Physiology, 121, 2, 2021, 409 - 423 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/94035 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Purpose: The time constant of phase II pulmonary oxygen uptake kinetics ([Formula: see text]) is increased when high-intensity exercise is initiated from an elevated baseline (work-to-work). A high-intensity priming exercise (PE), which enhances muscle oxygen supply, does not reduce this prolonged [Formula: see text] in healthy active individuals, likely because [Formula: see text] is limited by metabolic inertia (rather than oxygen delivery) in these individuals. Since [Formula: see text] is more influenced by oxygen delivery in type 2 diabetes (T2D), this study tested the hypothesis that PE would reduce [Formula: see text] in T2D during work-to-work cycle exercise.
Methods: Nine middle-aged individuals with T2D and nine controls (ND) performed four bouts of constant-load, high-intensity work-to-work transitions, each commencing from a baseline of moderate-intensity. Two bouts were completed without PE and two were preceded by PE. The rate of muscle deoxygenation ([HHb + Mb]) and surface integrated electromyography (iEMG) were measured at the right and left vastus lateralis, respectively.
Results: Subsequent to PE, [Formula: see text] was reduced (P = 0.001) in T2D (from 59 ± 17 to 37 ± 20 s) but not (P = 0.24) in ND (44 ± 10 to 38 ± 7 s). The amplitude of the [Formula: see text] slow component ([Formula: see text]2 As) was reduced (P = 0.001) in both groups (T2D: 0.16 ± 0.09 to 0.11 ± 0.04 l/min; ND: 0.21 ± 0.13 to 0.13 ± 0.09 l/min). This was accompanied by a reduction in ΔiEMG from the onset of [Formula: see text] slow component to end-exercise in both groups (P < 0.001), while [HHb + Mb] kinetics remained unchanged.
Conclusions: PE accelerates [Formula: see text] in T2D, likely by negating the O2 delivery limitation extant in the unprimed condition, and reduces the [Formula: see text]As possibly due to changes in muscle fibre activation. | en |
dc.format.extent | 409 | en |
dc.format.extent | 423 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | European Journal of Applied Physiology | en |
dc.relation.ispartofseries | 121 | en |
dc.relation.ispartofseries | 2 | en |
dc.rights | Y | en |
dc.subject | Near-infrared spectroscopy | en |
dc.subject | Oxygen extraction | en |
dc.subject | Oxygen uptake slow component | en |
dc.subject | Cycling | en |
dc.subject | Electromyography | en |
dc.title | Priming exercise accelerates pulmonary oxygen uptake kinetics during "work-to-work" cycle exercise in middle-aged individuals with type 2 diabetes | en |
dc.type | Journal Article | en |
dc.contributor.sponsor | Health Research Board (HRB) | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/megana | en |
dc.identifier.rssinternalid | 221318 | en |
dc.identifier.doi | http://dx.doi.org/10.1007/s00421-020-04518-y | en |
dc.rights.ecaccessrights | openAccess | |
dc.contributor.sponsorGrantNumber | HRA_POR/2073/274 | en |
dc.subject.TCDTag | Aerobic exercise | en |
dc.subject.TCDTag | EXERCISE TOLERANCE | en |
dc.subject.TCDTag | Exercise Medicine | en |
dc.subject.TCDTag | Exercise physiology | en |
dc.subject.TCDTag | OXYGEN UPTAKE | en |
dc.subject.TCDTag | TYPE 2 DIABETES | en |
dc.identifier.rssuri | https://link.springer.com/article/10.1007/s00421-020-04518-y | en |
dc.identifier.orcid_id | 0000-0003-1984-9250 | en |
dc.status.accessible | N | en |