Lack Of Association Between Angiotensin-converting Enzyme (Ace) Genotype And Essential Hypertension In Peruvian Older People
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2020Author:
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Oscanoa, T.J., Cieza, E.C.,. Lizaraso-Soto, F.A., Guevara, M.L., Fujita, R.M. & Romero-Ortuno, R., Lack Of Association Between Angiotensin-converting Enzyme (Ace) Genotype And Essential Hypertension In Peruvian Older People, Arterial Hypertension, 2020, 24, 3, 115-119Download Item:
Abstract:
Background: Epidemiological studies have shown an association between the ACE gene I / D polymorphism with arterial hypertension, specifically the DD genotype in different populations. The objective of this study is to evaluate the association between ACE polymorphisms (Insertion, Deletion or I/D) and essential hypertension in a population of Lima, Peru. Material and methods This is a study of cases (essential arterial hypertension) and controls, with determination of the ACE I/D genotype. Results Cases (65) and controls (39) had a mean age (standard deviation) of 74.3 (7.9) and 72.6 (6.5) (p = 0.24). In cases, the genotype frequencies DD, ID, and II were 6 (9.2%), 28 (43.1%) and 31 (47.7%), respectively. In controls, the genotype frequencies DD, ID, and II were 6 (15.4%), 14 (35.9%) and 19 (48.7%). The Hardy – Weinberg equilibrium analysis in cases and controls was p = 0.93 and p = 0.23, respectively. No significant associations between genotype DD vs ID+II (OR = 0.56, 95% CI 0.17-1.87, p = 0.34) or II vs DD+ID (OR = 0.95, 95% CI, 0.43 - 2.12, p = 0.92) and essential hypertension were found.
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Author: Romero-Ortuno, Roman; Oscanoa, Teodoro J.; Cieza, Edwin C.; Lizaraso-Soto, Frank A.; Guevara, Maria L.; Fujita, Ricardo M.
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Arterial Hypertension;Availability:
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Hypertension, Renin-angiotensin system, Genetic polymorphism, Angiotensin converting enzyme, PeruSubject (TCD):
AgeingDOI:
10.5603/AH.a2020.0011Metadata
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