Changes in Muscle Strength and Physical Function in Older Patients During and After Hospitalisation: a Prospective Repeated-Measures Cohort Study
File Type:
PDFItem Type:
Journal ArticleDate:
2020Author:
Access:
openAccessCitation:
Hartley P, Romero-Ortuno R, Wellwood I, Deaton C, Changes in Muscle Strength and Physical Function in Older Patients During and After Hospitalisation: a Prospective Repeated-Measures Cohort Study, Age and Ageing, 2020Download Item:
AA paper PH .pdf (Accepted for publication (author's copy) - Peer Reviewed) 403.1Kb
Abstract:
Aim: To investigate changes in knee-extension strength and physical function in older adults during and after acute hospital admission, and the contributions of illness severity, frailty and sedentary activity to changes in knee-extension strength.Methods: Prospective repeated-measures cohort study on a sample of participants aged ≥75 recruited within 24 hours of acute hospital admission. Knee-extension, grip strength and functional mobility (de Morton Mobility Index (DEMMI) were measured at recruitment, day 7 (or discharge if earlier), and at follow-up 4-6 weeks later.During the first 7 days, continuous measurement of physical activity and daily measurements of muscle strength were taken. Participants recalled the functional ability they had 2-weeks before admission and self-reported it at follow-up (Barthel Index). Results Sixty-five of 70participants (median age 84 years) had at least one repeated measure of muscle strength in hospital. Knee-extension strength declined during hospitalisation by 11% (p < 0.001) but did not change post-hospitalisation (p = 0.458). Grip strength did not change during hospitalisation (p = 0.665) or from discharge to follow-up (p = 0.508). General functional ability (Barthel Index) deteriorated between 2 weeks before admission and follow-up (p < 0.001). Functional mobility (DEMMI) improved during hospitalisation (p < 0.001) but did not change post-hospitalisation (p = 0.508). A repeated-measures mixed model showed that greater loss in knee-extension strength during hospitalisation was associated with increased sedentary time, frailty, and baseline strength, and lower baseline inflammatory levels.Conclusions: Our observations add to a growing body of evidence on potential risk factors for hospital-associated deconditioning.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
18/FRL/6188
Author's Homepage:
http://people.tcd.ie/romeroorDescription:
PUBLISHED
Author: Romero-Ortuno, Roman
Type of material:
Journal ArticleCollections:
Series/Report no:
Age and AgeingAvailability:
Full text availableKeywords:
Hospital, Deconditioning, Activity, Frailty, Strength, Older peopleSubject (TCD):
AgeingDOI:
https://doi.org/10.1093/ageing/afaa103Licences: