dc.contributor.author | FITZGERALD, MICHAEL | |
dc.contributor.author | Nugent, E. | |
dc.contributor.author | Hawi, Z. | |
dc.contributor.author | Lowe, N. | |
dc.contributor.author | Kirley, A. | |
dc.contributor.author | Gill, M. | |
dc.date.accessioned | 2020-04-28T10:27:35Z | |
dc.date.available | 2020-04-28T10:27:35Z | |
dc.date.issued | 1999 | |
dc.date.submitted | 1999 | en |
dc.identifier.citation | Nugent E., Hawi Z., Lowe N., Kirley A., Fitzgerald M. & Gill M. , Attention Deficit Hyperactivity Disorder (ADHD) and 5-HT2C receptor: A slight increase in the transmission of Cys23 to ADHD cases, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 105, 7, 1999, 637 | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://professormichaelfitzgerald.eu/ | |
dc.identifier.uri | http://hdl.handle.net/2262/92387 | |
dc.description.abstract | Recent evidence suggests that interaction with and balancebetween serotonergicand dopaminergic neurotransmissionis important in the mediation of hyperactive behaviour.Animal model studies have ®rmly implicated the genes of theserotonergic system in predisposing to ADHD. Serotoninexerts its effects via a heterogenous family of receptors ofwhich there are at least 14 distinct subtypes.The non-speci®c serotonin receptor agonist (m-chlorophenylpiperazine)is known to suppress locomotion in normalmice. However, when administered to mice bearing amutated 5-HTR2C gene, it induces hyperactivity in theseanimals (Lora et al., 2000). This effect was blocked by pretreatmentwith 5HT1B receptor antagonist, indicating thatthe behavioural consequences of the mCPP-induced 5HT1Breceptor stimulation are unmasked in animals devoid of5HT2C receptor function. A Cysteine to Serine substitutionat amino acid 23 of the 5HT2C has been identi®ed whichmay in ̄uence the receptor folding thereby hindering the formation of a normal hydrophobic pocket and subsequentlythe binding of bulky ligands. In a family based associationstudy design, we analysed the Cys-Ser polymorphism at the5HT2C receptor gene in 60 Irish ADHD trios using transmissiondisequilibrium test (TDT). We observed a slightincrease in the transmission of the Cysteine allele to theaffected ADHD cases (Chi-square ˆ1.8, P ˆ 0.26). Thismay suggest the involvement of 5HT2C gene in predisposingto ADHD. | en |
dc.format.extent | 637 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics; | |
dc.relation.ispartofseries | 105; | |
dc.relation.ispartofseries | 7; | |
dc.rights | Y | en |
dc.subject | ADHD | en |
dc.subject | Serotonin | en |
dc.title | Attention Deficit Hyperactivity Disorder (ADHD) and 5-HT2C receptor: A slight increase in the transmission of Cys23 to ADHD cases | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/mifitzge | |
dc.identifier.rssinternalid | 98906 | |
dc.identifier.doi | doi/10.1002/ajmg.1595/pdf | |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Neuroscience | en |
dc.subject.TCDTag | 5-HT2C | en |
dc.subject.TCDTag | ADD/ADHD | en |
dc.subject.TCDTag | ADD/ADHD | en |
dc.subject.TCDTag | ADHD | en |
dc.subject.TCDTag | ADHD | en |
dc.subject.TCDTag | ADHD Lifetime Impairment Survey | en |
dc.subject.TCDTag | ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) | en |
dc.subject.TCDTag | Adolescent Psychiatry | en |
dc.subject.TCDTag | Attention Deficit Hyperactivity Disorder (ADHD) | en |
dc.subject.TCDTag | CHILD PSYCHIATRY | en |
dc.subject.TCDTag | COMMUNITY PSYCHIATRY | en |
dc.subject.TCDTag | CONSULTATION LIAISON PSYCHIATRY | en |
dc.subject.TCDTag | CONSULTATION-LIAISON PSYCHIATRY | en |
dc.subject.TCDTag | Cys23 | en |
dc.subject.TCDTag | DISORDER ADHD | en |
dc.subject.TCDTag | GENERAL HOSPITAL PSYCHIATRY | en |
dc.subject.TCDTag | LIAISON PSYCHIATRY | en |
dc.subject.TCDTag | Neuropsychiatry | en |
dc.subject.TCDTag | Neuropsychiatry | en |
dc.subject.TCDTag | PSYCHIATRY | en |
dc.subject.TCDTag | Psychiatry | en |
dc.subject.TCDTag | Psychiatry | en |
dc.subject.TCDTag | TRAINEES IN PSYCHIATRY | en |
dc.subject.TCDTag | adult ADHD | en |
dc.subject.TCDTag | child and adolescent Psychiatry | en |
dc.subject.TCDTag | neurodevelopmental psychiatry | en |