RSS 1.0Psychiatry
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Psychiatry (Scholarly Publications)
Psychiatry (Scholarly Publications)
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The phenotypic manifestations of rare genic CNVs in autism spectrum disorder.
(2014)Significant evidence exists for the association between copy number variants (CNVs) and Autism Spectrum Disorder (ASD); however, most of this work has focused solely on the diagnosis of ASD. There is limited understanding ... -
Review of statistical methodologies for the detection of parent-of-origin effects in family trio genome-wide association data with binary disease traits.
(2014)The detection of parent-of-origin effects aims to identify whether the functionality of alleles, and in turn associated phenotypic traits, depends on the parental origin of the alleles. Different parent-of-origin effects ... -
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
(2014)BACKGROUND: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify ... -
Inversion effects in the perception of the moving human form - A comparison of adolescents with autism spectrum disorder and typically developing adolescents
(2013)The “body inversion effect” refers to superior recognition of upright than inverted images of the human body and indicates typical configural processing. Previous research by Reed et al. using static images of the human ... -
Home environment: association with hyperactivity/impulsivity in children with ADHD and their non-ADHD siblings.
(2013)We wished to ascertain if there is an association between symptoms of attention-deficit/hyperactivity disorder (ADHD) and home environment in children with ADHD and non-ADHD siblings, controlling for other environmental ... -
Prognostic factors of 2-year outcomes of patients with comorbid bipolar disorder or depression with alcohol dependence: Importance of early abstinence
(2013)Aims: To investigate the prognostic factors that determine 2-year outcomes in a group of alcohol-dependent patients with depression or bipolar disorder who were treated in an intensive 4-week inpatient programme. Methods: This ... -
Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression.
(2013)BACKGROUND: Family history of major depressive disorder (MDD) increases individuals' vulnerability to depression and alters the way depression manifests itself. Emotion processing and attention shifting are functions ... -
Implementing a court diversion and liaison scheme in a remand prison by systematic screening of new receptions: a 6 year participatory action research study of 20,084 consecutive male remands.
(2013)BACKGROUND: A mental health needs assessment in the Irish prison population confirmed findings from other jurisdictions showing high prevalence of severe mental illness, including psychosis amongst those newly committed. ... -
Prospective study of factors influencing conditional discharge from a forensic hospital: the DUNDRUM-3 programme completion and DUNDRUM-4 recovery structured professional judgement instruments and risk
(BioMed Central Ltd, 2013)Background We set out to examine whether structured professional judgement instruments DUNDRUM-3 programme completion (D-3) and DUNDRUM-4 recovery (D-4) scales along with measures of risk, mental state and global function ... -
Duplications in RB1CC1 are associated with schizophrenia; identification in large European sample sets
(Nature Publishing Group, 2013)Schizophrenia (SCZ) is a severe and debilitating neuropsychiatric disorder with an estimated heritability of ~80%. Recently, de novo mutations, identified by next-generation sequencing (NGS) technology, have been suggested ... -
Susceptibility (risk and protective) factors for in-patient violence and self-harm: Prospective study of structured professional judgement instruments START and SAPROF, DUNDRUM-3 and DUNDRUM-4 in forensic mental health services
(2013)Background The START and SAPROF are newly developed fourth generation structured professional judgement instruments assessing strengths and protective factors. The DUNDRUM-3 and DUNDRUM-4 also measure positive factors, ... -
Sodium-23 Magnetic Resonance Imaging has potential for improving penumbra detection but not for estimating stroke onset time
(2014)Tissue sodium concentration increases in irreversibly damaged (core) tissue following ischemic stroke and can potentially help to differentiate the core from the adjacent hypoperfused but viable penumbra. To test this, ... -
Schizophrenia at a genetics crossroads: Where to now?
(2013)These are interesting times for schizophrenia genetics. The last 5 years has seen unprecedented progress, moving us from debate about putative genetic models to an understanding that susceptibility involves a complex ... -
Relapse following successful electroconvulsive therapy for major depression: A meta-analysis
(2013)High rates of early relapse following electroconvulsive therapy (ECT) are typically reported in the literature. Current treatment guidelines offer little information to clinicians on the optimal nature of maintenance therapy ... -
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.
(2012)Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and ... -
Mental health problems in children with prader-willi syndrome.
(2012)BACKGROUND: Prader-Willi Syndrome (PWS) is a genetically determined neurodevelopmental disorder, which occurs in approximately one in 22000 births. AIMS: This study aimed to investigate psychiatric characteristics of ... -
Individual common variants exert weak effects on the risk for autism spectrum disorderspi.
(2012)While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To ...