A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
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2019Access:
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Doherty W., Durr E.-M., Baddock H.T., Lee S.Y., McHugh P.J., Brown T., Senge M.O., Scanlan E.M., McGouran J.F., A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A, Organic and Biomolecular Chemistry, 17, 35, 2019, 8094 - 8105Download Item:
OBC Doherty.pdf (PDF) 1.103MbAbstract:
Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors.
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https://pubs.rsc.org/en/content/articlelanding/2019/OB/C9OB01133A#!divAbstracthttp://hdl.handle.net/2262/91282
Author's Homepage:
http://people.tcd.ie/jmcgourahttp://people.tcd.ie/scanlae
http://people.tcd.ie/sengem
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Journal ArticleURI:
https://pubs.rsc.org/en/content/articlelanding/2019/OB/C9OB01133A#!divAbstracthttp://hdl.handle.net/2262/91282
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Organic and Biomolecular Chemistry17
35
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DNA repair, Nuclease SNM1A, Cancer treatmentDOI:
http://dx.doi.org/10.1039/c9ob01133aISSN:
14770520Licences: