Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?
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2018Author:
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Kaminski JA, Schlagenhauf F, Rapp M, Awasthi S, Ruggeri B, Deserno L, Banaschewski T, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Desrivières S, Flor H, Frouin V, Garavan H, Gowland P, Ittermann B, Martinot JL, Martinot MP, Nees F, Orfanos DP, Paus T, Poustka L, Smolka MN, Fröhner JH, Walter H, Whelan R, Ripke S, Schumann G, Heinz A, IMAGEN consortium., Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?, Translational psychiatry, 8, 1, 2018, 169Download Item:
Abstract:
Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average
intelligence test results in the second half of the previous century within one generation is unlikely to be explained by
genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that
environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand
the recent observations of an association between dopamine-dependent encoding of reward prediction errors and
cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers
contributing to variance in cognitive test performance, and thus possibly contributing to the
“
missing heritability
”
between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475
healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1)
polygenic scores for intelligence, (2) epigenetic modi
fi
cation of
DRD2
gene, (3) gray matter density in striatum, and (4)
functional striatal activation elicited by temporarily surprising reward-predicting cues. Comparing the relative
importance for the prediction of gIQ in an overlapping subsample, our results demonstrate neurobiological correlates
of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modi
fi
cation of DRD2 receptor
gene, as well as functional striatal activation, known to in
fl
uence dopamine neurotransmission. Peripheral epigenetic
markers are in need of con
fi
rmation in the central nervous system and should be tested in longitudinal settings
speci
fi
cally assessing individual and environmental factors that modify epigenetic structure.
Author's Homepage:
http://people.tcd.ie/bokdeahttp://people.tcd.ie/whelanr3
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Author: Bokde, Arun; Whelan, Robert; Kaminski, Jakob A.; Schlagenhauf, Florian; Rapp, Michael; Awasthi, Swapnil; Ruggeri, Barbara; Deserno, Lorenz; Banaschewski, Tobias; Bromberg, Uli; Büchel, Christian; Burke Quinlan, Erin; Desrivieres, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Ittermann, Bernd; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Paus, Tomáš; Poustka, Luise; Smolka, Michael N.; Fröhner, Juliane H.; Walter, Henrik; Ripke, Stephan; Schumann, Gunter; Heinz, Andreas; the IMAGEN consortium
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Translational psychiatry;8;
1;
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Full text availableKeywords:
Cognitive test performance, IQ, DopamineDOI:
http://dx.doi.org/10.1038/s41398-018-0222-7ISSN:
2158-3188Metadata
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