Manganese: a new contrast agent for lung imaging?
File Type:
PDFItem Type:
Journal ArticleDate:
2012Access:
openAccessCitation:
Gobbo, O.L., Zurek, M., Tewes, F., Erhardt, C. & Cémillieux, Y., Manganese: a new contrast agent for lung imaging?, Contrast Media Mol I, 7, 6, 2012, 542-546Download Item:
Abstract:
Lung parenchyma remains one of the most difficult tissues to be imaged by means of magnetic resonance imaging
(MRI). Several MRI techniques are routinely used for lung imaging. However, manganese-enhancement MRI (MEMRI)
technique has not been associated with pulmonary MRI. Here, we evaluated T1-enhancement in the rat lung after a
manganese instillation, using a 4.7 T magnet with a radial ultrashort echo time sequence. Our data showed that the
signal intensity was increased in lungs receiving a manganese solution compared with a control solution to the
lungs. MR signal enhancements above 30% were measured in lung parenchyma following 200 ml instillation of
a 1 mM manganese chloride solution. MEMRI, therefore, may be a useful novel tool for enhancing signal intensity
and image contrast in lung tissue.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
Author's Homepage:
http://people.tcd.ie/ogobbohttp://people.tcd.ie/ehrhardc
Description:
PUBLISHEDType of material:
Journal ArticleSeries/Report no:
Contrast Media Mol I;7;
6;
Availability:
Full text availableKeywords:
MEMRI, Lung imaging, Manganese, Aerosol contrast agent, UTE lung MRISubject (TCD):
Immunology, Inflammation & InfectionDOI:
http://dx.doi.org/10.1002/cmmi.1483Metadata
Show full item recordLicences: