Design and biological activity of a novel bioactive indane scaffold
File Type:
PDFItem Type:
thesisDate:
2015Author:
Access:
openAccessCitation:
Vilmar Cláudio Banderó Filho, 'Design and biological activity of a novel bioactive indane scaffold', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015, pp 374Download Item:
Abstract:
This project is focussed on the design, synthesis and pharmacological evaluation of
novel drug-hybrids which combine anti-inflammatory and anti-tumour activities to target
the interface between inflammatory disease and cancer. Chemical aspects of this
study successfully demonstrate effective protection and coupling methodologies in
the synthesis of the novel hybrid scaffolds from simple substituted indanone and
benzophenone monomers. In addition to the targeted hybrids, self-condensation
products were generated during the study. Purification methods were successfully
developed and novel scaffolds were characterised by X-ray crystallography.
Author: Filho, Vilmar Cláudio Banderó
Advisor:
Sheridan, HelenQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical SciencesNote:
TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ieType of material:
thesisCollections
Availability:
Full text availableMetadata
Show full item recordLicences: