Carbon nano-onions as non-cytotoxic carriers for cellular uptake of glycopeptides and proteins
Citation:
d'Amora, M, Maffeis, V, Brescia, R, Barnes, D, Scanlan, E, Giordani, S. Carbon nano-onions as non-cytotoxic carriers for cellular uptake of glycopeptides and proteins, Nanomaterials, 2019, 9, 1069Download Item:
Abstract:
Carbon nano-onions (CNOs) possess favorable properties that make them suitable for biomedical applications, including their small size, ready surface modification, and good biocompatibility. Here, we report the covalent immobilization of a synthetic glycopeptide and the protein bovine serum albumin (BSA) onto the surface of carbon nano-onions using the maleimide–thiol “addition reaction”. The glycopeptide and BSA are readily transported inside different cell lines, together with carbon nano-onions, through the endocytosis pathway. Our results show that carbon nano-onions are excellent scaffolds for glycopeptides and proteins immobilization and act as intracellular carriers for these biomolecules. These findings open new perspectives in the application of carbon nano-onions as intracellular transporters in diverse biomedical applications.
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http://people.tcd.ie/scanlae
Author: Scanlan, Eoin
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MDPIType of material:
Journal ArticleCollections
Series/Report no:
Nanomaterials;9;
8;
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Full text availableKeywords:
Carbon nano-onions, Biomolecules, Scaffolds, Carriers, Biomedical applicationsDOI:
http://dx.doi.org/10.3390/nano9081069Metadata
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