The control of DNA gyrase expression and its role in deletion formation in Salmonella enterica
Citation:
Orla Mary Keane, 'The control of DNA gyrase expression and its role in deletion formation in Salmonella enterica', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2003, pp 270Download Item:
Keane TCD THESIS 7166 The control.pdf (PDF) 200.1Mb
Abstract:
Salmonella typhimurium strain CJD671 can undergo the deletion of a 5kb segment of
DNA from its large virulence plasmid. This results in a transcriptional fusion between the rlgA gene, encoding a putative site-specific resolvase, and the spvR virulence gene
regulator. The strong activity of the rlgA promoter results in the overexpression of a lacZ reporter gene in the spv locus. Deletions are selected for by lactose and only occur when the bacteria are grown at elevated osmolarity.
Author: Keane, Orla Mary
Advisor:
Dorman, CharlesQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical MicrobiologyNote:
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Full text availableKeywords:
Microbiology, Ph.D., Ph.D. Trinity College DublinLicences: