Clinical Microbiology (Theses and Dissertations)
Recent Submissions
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Evaluation of Next-Generation Sequencing to Investigate the Epidemiology of Clostridioides difficile Infection
Introduction: Clostridioides difficile (C. difficile) is an anaerobic bacteria, which can cause gastrointestinal infection. There are approximately 2,000 cases of C. difficile infection (CDI) diagnosed in Ireland per year, ... -
Inhibition of K-BALB murine tumours using Semliki Forest virus and its derived factor
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2005)The induction of cytopathic effects in tumour cells, often by apoptosis, is the primary goal of most non-surgical cancer therapies. Cancer gene therapy represents a variety of potentially therapeutic strategies involving ... -
Analysis and development of the recombinant Semliki Forest virus vector as a cancer gene therapy agent
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2001)Increased understanding of the molecular pathogenesis of cancer has shown that its accumulation is the result of multiple genetic alterations. Cancer is a disease of altered genes, with the most predominantly altered ... -
The molecular characterization of the clumping Factor A (ClfA) from Staphylococcus aureus using monoclonal antibodies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2000)Clumping factor (ClfA) of Staphylococcus aureus is the major fibrinogen- binding adhesin located on the cell surface of the bacterium. Monoclonal antibodies (mAbs) were produced to two recombinant truncated ClfA proteins, ... -
Functional analysis of the VirB protein of Shigella flexneri
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2003)The VirB protein is a key regulator of virulence gene expression in Shigella flexneri, a facultative enteroinvasive pathogen that causes bacillary dysentery. Genetic evidence has shown that VirB is required for the activation ... -
The role of beta-lactamase in low-level cephalosporin-resistant serratia marcescens
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2002)In enterobacteria, high-level cephalosporin resistance is commonly mediated by constitutive over-production or derepression of chromosomal AmpC β-lactamase. This derepression is frequently associated with mutations in ... -
The role of the Salmonella PagN protein in adhesion and invasion
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2015)Salmonella, an important genus of Gram-negative enteric bacteria, is the causative agent of many different diseases including Typhoid Fever and Gastroenteritis. Salmonella utilises multiple methods of invading mammalian ...