Browsing Genetics by Author "RAMASWAMI, MANI"
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Altered ribostasis: RNA-protein granules in degenerative disorders
RAMASWAMI, MANI (2013)The molecular processes that contribute to degenerative diseases are not well understood. Recent observations suggest that some degenerative diseases are promoted by the accumulation of nuclear or cytoplasmic RNA-protein ... -
Fly model causes neurological rethink
RAMASWAMI, MANI (2013)A Drosophila model for a neurological disorder called type 2B Charcot- Marie-Tooth disease reveals that it has its origins in a partial loss of function, rather than a gain of function, which points to the need for ... -
Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity
RAMASWAMI, MANI (2015)Neurodevelopmental disorders arise from single or multiple gene defects. However, the way multiple loci interact to modify phenotypic outcomes remains poorly understood. Here, we studied phenotypes associated with mutations ... -
A genome-wide resource for the analysis of protein localisation in Drosophila
RAMASWAMI, MANI (2016)The Drosophila genome contains >13000 protein-coding genes, the majority of which remain poorly investigated. Important reasons include the lack of antibodies or reporter constructs to visualise these proteins. Here, we ... -
Identification and Structural Characterization of Interneurons of the Drosophila Brain by Monoclonal Antibodies of the Wurzburg Hybridoma Library
RAMASWAMI, MANI (2013)Several novel synaptic proteins have been identified by monoclonal antibodies (mAbs) of the Würzburg hybridoma library generated against homogenized Drosophila brains, e.g. cysteine string protein, synapse-associated protein ... -
Network plasticity in adaptive filtering and behavioral habituation
RAMASWAMI, MANI (2014)The ability of organisms to seamlessly ignore familiar, inconsequential stimuli improves their selective attention and response to salient features of the environment. Here, I propose that this fundamental but unexplained ... -
A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila
RAMASWAMI, MANI (2010)Techniques to induce activity-dependent neuronal plasticity in vivo allow the underlying signaling pathways to be studied in their biological context. Here, we demonstrate activity-induced plasticity at neuromuscular ... -
Plasticity of recurrent inhibition in the Drosophila antennal lobe
RAMASWAMI, MANI (2012)Recurrent inhibition, wherein excitatory principal neurons stimulate inhibitory interneurons that feedback on the same principal cells, occurs ubiquitously in the brain. However, the regulation and function of recurrent ... -
Social communication of predator-induced changes in Drosophila behavior and germline physiology
RAMASWAMI, MANI (2015)Behavioral adaptation to environmental threats and subsequent social transmission of adaptive behavior has evolutionary implications. In Drosophila, exposure to parasitoid wasps leads to a sharp decline in oviposition. We ... -
Synapsin Function in GABA-ergic Interneurons Is Required for Short-Term Olfactory Habituation
RAMASWAMI, MANI (2013)In Drosophila, short-term (STH) and long-term habituation (LTH) of olfactory avoidance behavior are believed to arise from the selective potentiation of GABAergic synapses between multiglomerular local circuit interneurons ...