Browsing Genetics by Title
Now showing items 56-75 of 553
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Changes in alternative splicing of human and mouse genes are accompanied by faster evolution of constitutive exons
(Oxford University Press, 2005)Alternative splicing is known to be an important source of protein sequence variation, but its evolutionary impact has not been explored in detail. Studying alternative splicing requires extensive sampling of the transcriptome, ... -
A characterisation of gene duplicability: its determining factors and impact on duplicate evolution
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)Duplication, either through whole genome duplication or small-scale duplication, is a critical process in evolution. The duplication of genetic material provides ample opportunity for adaptation and innovation through the ... -
Characterisation of the Genetic Mechanism Behind Floral Trichomes in Brassica rapa
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)In his seminal essay ?The Metamorphosis of Plants?, published in the 18th century, Johann Wolfgang von Goethe hypothesized that all above-ground organs of a plant, including floral organs, are derived from leaf-like ... -
Characterisation of the second binding protein of immunoglobulin (SBi) in Straphylococcus aureus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)The second binding protein for immunoglobulin (Sbi) of Staphylococcus aureus comprises two IgG binding domains (D1 and D2) that share 30% sequence homology with the IgG binding domains of protein A (Spa) and two domains ... -
Characterising the effects of sex interaction, pleiotropy and local population structure on ALS GWAS
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)In the past decade, increasingly large-scale genome wide association studies (GWAS) have gleaned insights into the genetic architecture of a range of human traits. Widespread sharing of summary statistics for these GWAS ... -
Characterization of Arabidopsis homologs of the Drosophila SET domain gene Su(var)3-9
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)SET domain-containing proteins encoded by the Drosophila gene Su(var)3-9 and its human homologue, SUV39H1, are major regulators of heterochromatin formation. The SET domains of these proteins carry histone methyltransferase ... -
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription
(2005)The E2F family of transcription factors are downstream effectors of the retinoblastoma protein, pRB, pathway and are essential for the timely regulation of genes necessary for cell-cycle progression. Here we describe the ... -
Characterization of RP1L1, a highly polymorphic paralog of the retinitis pigmentosxa 1 (RP1) gene
(Molecular Vision, 2003)PURPOSE: To determine the full-length sequence of a gene with similarity to RP1 and to screen for mutations in this newly characterized gene, named retinitis pigmentosa 1-like 1(RP1L1). Since mutations in the RP1 gene cause ... -
Characterization of two flowering gene homologues from Lolium perenne
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)Lolium perenne (perennial ryegrass) is a primary source of fodder for grazing cattle and is therefore of significant agricultural and economic importance. Understanding the flowering process in this species may help to ... -
Characterization of two genes transcribed from a divergent promotor in Arabidopsis thaliana and encoding plastid-targeted proteins
(Trinity College (Dublin, Ireland). Department of Genetics, 2001)As part of the Arabidopsis genome sequencing project, approximately 85kb of sequence data on chromosome 4 was generated in this laboratory. This included a cosmid clone called cAt4S5 containing a genomic insert of 13.3kb ... -
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression
(2013)The chromatin remodeler CHD5 is expressed in neu- ral tissue and is frequently deleted in aggressive neuroblastoma.Verylittleisknownaboutthefunction of CHD5 in the nervous system or its mechanism of action. Here we ... -
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression.
(2013)The chromatin remodeler CHD5 is expressed in neural tissue and is frequently deleted in aggressive neuroblastoma. Very little is known about the function of CHD5 in the nervous system or its mechanism of action. Here we ... -
ChloroMitoSSRDB: open source repository of perfect and imperfect repeats in organelle genomes for evolutionary genomics.
(2013)Microsatellites or simple sequence repeats (SSRs) are repetitive stretches of nucleotides (A, T, G, C) that are distributed either as single base pair stretches or as a combination of two- to six-nucleotides units that are ... -
A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
(2015)Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three ... -
Chromosomal G + C content evolution in yeasts: systematic interspecies differences, and GC-poor troughs at centromeres.
(2010)The G + C content at synonymous codon positions (GC3s) in genes varies along chromosomes in most eukaryotes. In Saccharomyces cerevisiae, regions of high GC3s are correlated with recombination hot spots, probably due to ... -
Claudin-5 expression at the Blood Brain Barrier and its therapeutic potential in neurological disease
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Breakdown of the blood brain barrier's (BBB) integrity is a hallmark pathology in numerous neurological disorders. However, while research and therapeutic development has mostly focussed on neuronal function, the high ... -
Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier
(2021)Claudin-5 is the dominant tight junction protein in brain endothelial cells and exclusively limits the paracellular permeability of molecules larger than 400Da across the blood–brain barrier (BBB). Its pathological impairment ... -
Claudin-5: Gatekeeper of neurological function
(2019)Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of endothelial cells lining brain blood vessels. The presence of these protein complexes in the space between endothelial cells creates ... -
Clinical and Genetic Re-Evaluation of Inherited Retinal Degeneration Pedigrees following Initial Negative Findings on Panel-Based Next Generation Sequencing
(2022)Although rare, inherited retinal degenerations (IRDs) are the most common reason for blind registration in the working age population. They are highly genetically heterogeneous (>300 known genetic loci), and confirmation ...