CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression
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2013Access:
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Egan,Chris M. C.M., Nyman,Ulrika U., Skotte,Julie J., Streubel,Gundula G., Turner,Siobhán A. S.A., O'Connell,David J. D.J., Rraklli,Vilma V., Dolan,Michael J. M.J., Chadderton,Naomi S. N.S., Hansen,Klaus H. K.H., Farrar,Gwyneth Jane G.J., Helin,Kristian K., Holmberg,Johan T. J.T., Bracken,Adrian P. A.P., CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression, Developmental Cell, 26, 3, 2013, 223-236Download Item:
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Abstract:
The chromatin remodeler CHD5 is expressed in neu-
ral tissue and is frequently deleted in aggressive
neuroblastoma.Verylittleisknownaboutthefunction
of CHD5 in the nervous system or its mechanism of
action. Here we report that depletion of
Chd5
in the
developingneocortex blocks neuronal differentiation
and leads to an accumulation of undifferentiated
progenitors. CHD5 binds a large cohort of genes
and is required for facilitating the activation of
neuronal genes. It also binds a cohort of Poly-
comb targets and is required for the maintenance
of H3K27me3 on these genes. Interestingly, the chro-
modomainsofCHD5directlybindH3K27me3andare
required for neuronal differentiation. In the absence
of CHD5, a subgroup of Polycomb-repressed genes
becomes aberrantly expressed. These findings pro-
vide insights into the regulatory role of CHD5 during
neurogenesis and suggest how inactivation of this
candidate tumor suppressor might contribute to
neuroblastoma.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
SFI PICA SFI/10/IN.1/B3002
Author's Homepage:
http://people.tcd.ie/streubeghttp://people.tcd.ie/kahokamp
Description:
PUBLISHED
Author: STREUBEL, GUNDULA; HOKAMP, KARSTEN
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Series/Report no:
Developmental Cell26
3
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Full text availableKeywords:
Polycomb-repressed genesDOI:
http://dx.doi.org/10.1016/j.devcel.2013.07.008ISSN:
15345807Licences: