Browsing Genetics by Title
Now showing items 270-289 of 552
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Interacting gene clusters and the evolution of the vertebrate immune system.
(2008)Unraveling the "code" of genome structure is an important goal of genomics research. Colocalization of genes in eukaryotic genomes may facilitate preservation of favorable allele combinations between epistasic loci or ... -
Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation
(2004)Caspases coordinate the internal demolition of the cell that is seen during apoptosis. Proteolytic processing of caspases is observed during apoptosis, and this correlates with conversion of inactive caspase proenzymes ... -
Interpretation and improvement of the current genetic epidemiology methodology for schizophrenia
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Recent technological advancements have allowed for the development of new methodologies in the investigation of the genetic epidemiology of schizophrenia. Two of the most prominent methods in that field are the Polygenic ... -
Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.
(2013)Leber hereditary optic neuropathy (LHON) is a mitochondrially inherited form of visual dysfunction caused by mutations in several genes encoding subunits of the mitochondrial respiratory NADH-ubiquinone oxidoreductase ... -
Investigating mechanisms underlying olfactory habituation in Drosophila melanogaster
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)Habituation is a common form of learning and memory that has been poorly studied despite its fundamental importance and clinical significance. During habituation, the behavioural response to a prolonged or repeated ... -
Investigating Polycomb group proteins as genetic dependencies in H3-K27M mutant paediatric glioma.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Polycomb group proteins play an important role in the maintenance of cellular identity by contributing to transcriptional repression through the regulation of chromatin structure. These proteins form two main multimeric ... -
Investigating the Circadian Regulation of the Inner Blood Retinal Barrier in Early and Intermediate Age-Related Macular Degeneration
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)Age-related macular degeneration (AMD) is the leading cause of central visual impairment worldwide. It is a multifactorial condition leading to the painless, progressive loss of central vision. There are currently no ... -
Investigating the molecular mechanisms that control the transformation of leaves into floral organs.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)Arabidopsis thaliana is the model plant which has been used to elucidate the molecular and genetic processes which underlie floral organogenesis. This is the process in which the four floral organs are formed which is ... -
Investigating the Role of the 3'UTR of Claudin-5 and Circadian Rhythms at Tight Junctions in the Blood-Brain Barrier
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2020)The blood-brain barrier (BBB) is comprised of the vasculature surrounding the central nervous system (CNS), and most importantly consists of endothelial cells. These brain endothelial cells have unique properties that ... -
Investigating the roles of SMARCA4 and EP300 in synovial sarcoma
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Synovial sarcoma is a rare and aggressive cancer that accounts for approximately 10% of all soft tissue sarcomas diagnosed annually. This malignancy is caused by a characteristic fusion protein known as SS18- SSX and is ... -
Investigating the roles of transmembrane semaphorins on thalamocortical connectivity
(Trinity College (Dublin, Ireland). Department of Genetics, 2009)The functional properties of structures in the central nervous system are critically dependent on the precision of neuronal connectivity. The cerebral cortex receives most of its input from the environment through ... -
Investigation of the immunophilin interactome of malarial parasites
(Trinity College (Dublin, Ireland). Department of Genetics, 2014)Malaria presents a significant global challenge in both human and economic terms. Approximately 40% of the population of the planet are at risk of contracting malaria, leading to an estimated 225 million cases and ... -
Investigation of the molecular mechanisms of functional innovation
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The robustness to perturbations and evolvability of genomes are two major principles that govern the emergence of genetic diversity across all forms of life. Functional innovations that occur through the genetic diversity ... -
Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis. Michael Prunty The PhoPR two-component signal transduction system (TCS) ... -
Investigation of the regulation of Bcl-2 family members in apoptosis and cancer
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)Apoptosis is a highly controlled mechanism of cell suicide that is activated in response to cellular stress and damage. The Bcl-2 family of proteins play a key role in the regulation of this process. Opposing subsets of ... -
Investigation of the role of the BcI-2 family proteins in Ras-induced transformation
(Trinity College (Dublin, Ireland). Department of Genetics, 2011)RAS is a proto-oncogene that is found mutated in 25% of human tumours. Deregulated Ras expression is typically insufficient to transform cells as it triggers anti-proliferative responses that altogether limit tumorigenesis. ... -
Investigation of the YycFG two-component signal transduction system in Bacillus subtilis
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The work in this thesis describes a novel approach to investigating the YycFG two-component signal transduction system of Bacillus subtilis. The YycFG TCSTS was found to be the only essential two-component signal transduction ... -
Investigation of transcriptome changes during flower development using third-generation sequencing and inducible gene perturbation approaches
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Over the last 30 years, flower development has been intensively studied us- ing a wide range of genetic and molecular methods. Much of this work was guided by the ABC model of floral organ identity specification, which ... -
Investigations on apoptosis-associated caspase activation cascades
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)Apoptosis is an important process in a wide variety of different biological systems such as the immune system, normal cell turnover and embryonic development (Stennicke et al., 2002). Apoptosis is characterized by a series ... -
Iron regulated surface determinants of Staphylococcus aureus and S. lugdunensis : their roles in pathogen-host interactions
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)Staphylococcus aureus is a human pathogen that causes invasive infections. The ability to internalize into and persist within host cells is thought to contribute to pathogenesis. The study described here has identified a ...