Browsing Genetics by Title
Now showing items 227-246 of 552
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A genome-wide association study for genetic susceptibility to Mycobacterium bovis infection in dairy cattle identifies a susceptibility QTL on chromosome 23
(2016)Background Bovine tuberculosis (bTB) infection in cattle is a significant economic concern in many countries, with annual costs to the UK and Irish governments of approximately €190 million and €63 million, respectively, ... -
A genome-wide association study for somatic cell score using the Illumina high-density bovine beadchip identifies several novel QTL potentially related to mastitis susceptibility
(2013)Mastitis is an inflammation-driven disease of the bovine mammary gland that occurs in response to physical damage or infection and is one of the most costly production-related diseases in the dairy industry worldwide. We ... -
Genome-wide associations for milk production and somatic cell score in Holstein-Friesian cattle in Ireland
(2012)Background: Contemporary dairy breeding goals have broadened to include, along with milk production traits, a number of non-production-related traits in an effort to improve the overall functionality of the dairy cow. ... -
Genome-wide data from two early Neolithic East Asian individuals dating to 7700 years ago
(2017)Ancient genomes have revolutionized our understanding of Holocene prehistory and, particularly, the Neolithic transition in western Eurasia. In contrast, East Asia has so far received little attention, despite ... -
Genome-wide deserts for copy number variation in vertebrates
(2013)Most copy number variations are neutral, but some are deleterious and associated with various human diseases. Copy number variations are distributed non-randomly in vertebrate genomes, and it was recently reported that ... -
Genome-Wide Functional Divergence after the Symbiosis of Proteobacteria with Insects Unraveled through a Novel Computational Approach
(2009)Symbiosis has been among the most important evolutionary steps to generate biological complexity. The establishment of symbiosis required an intimate metabolic link between biological systems with different complexity ... -
Genome-wide Mapping of Polycomb Target Genes Unravels Their Roles in Cell Fate Transitions.
(2006)The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential for embryonic development and stem cell renewal and are commonly deregulated in cancer. Here, we identify their target genes using ... -
A genome-wide resource for the analysis of protein localisation in Drosophila
(2016)The Drosophila genome contains >13000 protein-coding genes, the majority of which remain poorly investigated. Important reasons include the lack of antibodies or reporter constructs to visualise these proteins. Here, we ... -
Genomes as documents of evolutionary history: A probabilistic macrosynteny model for the reconstruction of ancestral genomes
(2017)Motivation: It has been argued that whole-genome duplication (WGD) exerted a profound influence on the course of evolution. For the purpose of fully understanding the impact of WGD, several formal algorithms have been ... -
Genomewide admixture mapping of African cattle
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)Genome-wide SNP analyses of cattle populations have become practical. In parallel, advanced and sophisticated statistical packages make it practical to extract embedded genetic information; for example differential levels ... -
Genomic evolution of polyploid yeast species
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)In Chapter 2 of this thesis I study how the genome structure and content of yeast has evolved since a Whole Genome Duplication (WGD) occurred in the lineage approximately 100 million years ago. By using genome data from ... -
Genomic Features in the Breakpoint Regions between Syntenic Blocks
(Oxford University Press, 2004)MOTIVATION: We study the largely unaligned regions between the syntenic blocks conserved in humans and mice, based on data extracted from the UCSC genome browser. These regions contain evolutionary breakpoints caused by ... -
Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus
(PLoS, 2008)We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri NRRL181 and Aspergillus ... -
Genomic signals of migration and continuity in Britain before the Anglo-Saxons
(2016)The purported migrations that have formed the peoples of Britain have been the focus of generations of scholarly controversy. However, this has not benefited from direct analyses of ancient genomes. Here we report nine ... -
Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis
(2012)BACKGROUND: Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cell types to encounter M. bovis following exposure ... -
GlycoRDF: An ontology to standardize glycomics data in RDF
(2015)Motivation: Over the last decades several glycomics-based bioinformatics resources and databases have been created and released to the public. Unfortunately, there is no common standard in the representation of the stored ... -
Going fast and getting lost : gene duplication in yeast
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)In this thesis I study how duplicate gene pairs created by a whole-genome duplication in an ancestor of several yeast species were resolved. I show that gene duplication may lead not just to the emergence of new gene ... -
Greasing the path to BAX/BAK activation
(2012)BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the ...