The role of the cyclooxygenase-2 - prostaglandin E2 cascade in pancreatic cancer associated angiogenesis
Citation:Desmond P. Toomey, 'The role of the cyclooxygenase-2 - prostaglandin E2 cascade in pancreatic cancer associated angiogenesis', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010, pp 147
Toomey TCD THESIS 9233 The role.pdf (PDF) 67.12Mb
Medical therapy has failed to make any significant impact on survival in pancreatic cancer. Non Steroidal Anti-inflammatory Drugs (NSAIDs) have shown promise in several gastrointestinal (Gl) cancers. Evidence has suggested a similar effect in pancreatic cancer. Cyclooxygenase-2 (COX-2), a major target of NSAIDs, is upregulated in pancreatic cancer and is associated with worse prognosis. COX-2 upregulation has been shown to correlate with angiogenesis and production of pro- angiogenic growth factors, especially Vascular Endothelial Growth Factor (VEGF), in several Gl cancers. Although this relationship between COX-2 and angiogenesis in pancreatic cancer would seem a viable target, clinical trials of COX-2 or VEGF inhibitors have demonstrated no survival benefit.
Author: Toomey, Desmond P.
Publisher:Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery
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Type of material:thesis
Availability:Full text available