Recent Submissions

  • Molecular analysis of cell proliferation and apoptosis in oesophageal adenocarcinoma 

    Raouf, Ali A. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2002)
    Cancer of the oesophagus is a particularly virulent gastrointestinal malignancy with poor prognosis. Replacement of the nomial squamous epithelium of the oesophagus with columnar epithelium (Barrett’s oesophagus) as a ...
  • The immunomodulatory chemokine CCL28 in oesophageal disease progression 

    Picardo, Sarah Louise (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)
    Barrett’s oesophagus (BO) develops in response to bile acid reflux and confers increased risk of progression to oesophageal adenocarcinoma (OAC). During this disease progression, the immune microenvironment of the oesophageal ...
  • Mitochondrial dysfunction during disease progression in Barrett's oesophagus 

    O'Farrell, Naoimh (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)
    Barrett’s oesophagus is the leading risk factor for oesophageal adenocarcinoma. However, it is difficult to identify patients at risk of disease progression. Mitochondria are highly susceptible to mutations due to high ...
  • Mechanisms linking obesity, genomic instability and the radioresponse in oesophageal adenocarcinoma 

    Mongan, Ann Marie (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)
    The increasing incidence of oesophageal adenocarcinoma (OAC) parallels the rapidly rising incidence of obesity. OAC is an exemplar model of obesity-associated cancer, with an increasing focus on the role of visceral adipose ...
  • Gene expression profiling in patients with severe sepsis 

    Grealy, Christopher Robert (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)
    The human response to infection ranges from mild illness which is relatively well tolerated to a severe, potentially life-threatening syndrome termed severe sepsis. This thesis explored this response in patients hospitalised ...

View more