Recent Submissions

  • Cytokine mRNA gene expression profiles in human host response to infection and sepis 

    White, Mary (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2013)
    This thesis explores the hypothesis that a cytokine mediated immune response modulates the human immune response to infection. Attenuation of this cytokine response may increase the risk of infection and sepsis in humans.
  • The role of the cyclooxygenase-2 - prostaglandin E2 cascade in pancreatic cancer associated angiogenesis 

    Toomey, Desmond P. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)
    Medical therapy has failed to make any significant impact on survival in pancreatic cancer. Non Steroidal Anti-inflammatory Drugs (NSAIDs) have shown promise in several gastrointestinal (Gl) cancers. Evidence has suggested ...
  • Local and systemic inflammation in oesophageal disease 

    Murphy, James Oliver (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)
    Background: Reflux-induced injury and oxidative stress result in oesophageal inflammation and the potential for progression to intestinal metaplasia and adenocarcinoma. Proton-pump inhibitors represent the standard medical ...
  • Obesity and cancer 

    Healy, Laura (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)
    Cancer rates are increasing with predictions of incidence rates doubling between 2000 and 2020. Although several factors are contributory, the rising incidence of overweight and obesity is currently thought to be fuelling ...
  • Molecular and radiological prediction of response to neo-adjuvant chemoradiation in patients with oesophageal cancer 

    Gillham, Charles Martin (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2009)
    The initial phase of the project’s laboratory component involved optimising techniques that would become necessary when analysing fresh oesophageal tissue. There are a number of commercially available techniques for tissue ...

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