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dc.contributor.advisorMarignol, Laure
dc.contributor.authorMartin, Lynn
dc.date.accessioned2017-01-19T16:20:59Z
dc.date.available2017-01-19T16:20:59Z
dc.date.issued2010
dc.identifier.citationLynn Martin, 'DNA mismatch repair and low dose hyper-radiosensitivity in prostate cancer cells', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Radiation Therapy, 2010, pp 246
dc.identifier.otherTHESIS 9291
dc.identifier.urihttp://hdl.handle.net/2262/79109
dc.description.abstractLow-dose hyper-radiosensitivity (HRS) describes the excessive sensitivity of cells to radiation doses less than 0.3Gy. Evidence suggests that HRS may influence tumour response and normal tissue reactions after intensity modulated radiotherapy and low dose rate brachytherapy, and that the response may potentially be exploited to improve therapeutic efficacy. Prostate cancer (PCa) is particularly likely to be affected by HRS due to the increasing use of protocols that involve low doses of radiation or low dose rates used in the radiotherapeutic management of the disease. While accumulating evidence indicates that DNA repair and G2 checkpoint responses are involved in the manifestation of HRS, the underlying mechanism(s) remains unknown. Elucidation of the mechanism(s) of the response is fundamental to understanding the true implications of HRS for radiotherapy practice.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Medicine. Discipline of Radiation Therapy
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb14862975
dc.subjectRadiation Therapy, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleDNA mismatch repair and low dose hyper-radiosensitivity in prostate cancer cells
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 246
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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