Browsing Mechanical, Manufacturing & Biomedical Eng by Author "Hoey, David"
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Biofabrication of vasculature in microphysiological models of bone.
Hoey, David; Kelly, Daniel (2021)Bone contains a dense network of blood vessels that are essential to its homoeostasis, endocrine function, mineral metabolism and regenerative functions. In addition, bone vasculature is implicated in a number of prominent ... -
Biomimetic Hyaluronic Acid-Lysozyme Composite Coating on AZ31 Mg Alloy with Combined Antibacterial and Osteoinductive Activities
Hoey, David; Agarwal, Sankalp; Riffault, Mathieu; Duffy, Brendan; Curtin, James; Jaiswal, Swarna (2017)This study presents the covalent grafting of a hyaluronic acid-lysozyme (HA-LZ) composite onto corrosion-resistant silane-coated AZ31 Mg alloy via EDC-NHS coupling reactions. The HA-LZ composite coatings created a smooth ... -
Ciliotherapy Treatments to Enhance Biochemically- and Biophysically-Induced Mesenchymal Stem Cell Osteogenesis: A Comparison Study
Hoey, David (2019)New approaches to treat osteoporosis have focused on promoting bone formation through the targeting of osteoblasts and their progenitors, mesenchymal stem cells (MSCs). The primary cilium is a singular cellular extension ... -
Development of a New Bone¿Mimetic Surface Treatment Platform: Nanoneedle Hydroxyapatite (nnHA) Coating
Hoey, David; Kelly, Daniel (2020)The hierarchical structure of bone plays pivotal roles in driving cell behavior and tissue regeneration and must be considered when designing materials for orthopedic applications. Herein, it is aimed to recapitulate the ... -
Direct mechanical characterization of prostate tissue-a systematic review.
Hoey, David (2018)Background Direct mechanical characterisation of tissue is the application of engineering techniques to biological tissue to ascertain stiffness or elasticity, which can change in response to disease states. A number of ... -
The effect of pore size within fibrous scaffolds fabricated using melt electrowriting on human bone marrow stem cell osteogenesis.
Hoey, David (2019)Limitations associated with current bone grafting materials has necessitated the development of synthetic scaffolds that mimic the native tissue for bone repair. Scaffold parameters such as pore size, pore interconnectivity, ... -
Electrospun Poly-D-L-lactic acid fibrous scaffolds as a delivery vehicle for calcium phosphate salts to promote in situ mineralisation and bone regeneration
Hoey, David (2018)Polymeric scaffolds and calcium phosphate cements have both shown promise in treating bone defects, whereby the former facilitates cell-mediated repair over long periods, while the latter facilitates rapid defect filling ... -
Enhanced corrosion resistance and cytocompatibility of biomimetic hyaluronic acid functionalised silane coating on AZ31 Mg alloy for orthopaedic applications.
Hoey, David; Agarwal, Sankalp; Morshed, Muhammad; Labour, Marie-Noelle; Duffy, Brendan; Curtin, James; Jaiswal, Swarna (2018)This paper reports the corrosion resistant and cytocompatible properties of the hyaluronic acid-silane coating on AZ31 Mg alloy. In this study, the osteoinductive properties of high molecular weight hyaluronic acid (HA, ... -
Estrogen deficiency impairs integrin ¿vß3-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling.
Hoey, David (2019)The integrin αvβ3 has been shown to play an important role in osteocyte mechanotransduction. It has been reported that there are fewer β3 integrin-containing cells in osteoporotic bone cells. Osteocytes cultured in vitro ... -
Estrogen withdrawal alters cytoskeletal and primary ciliary dynamics resulting in increased Hedgehog and osteoclastogenic paracrine signalling in osteocytes.
Hoey, David (2021)Estrogen deficiency during post-menopausal osteoporosis leads to osteoclastogenesis and bone loss. Increased pro-osteoclastogenic signalling (RANKL/OPG) by osteocytes occurs following estrogen withdrawal (EW) and is ... -
Genomic identification, expression profiling, and functional characterization of CatSper channels in the bovine
Hoey, David (2017)Cation channels of sperm (CatSper) are sperm-specific calcium channels with identified roles in the regulation of sperm function in humans, mice, and horses. We sought to employ a comparative genomics approach to identify ... -
How to design, develop and build a fully-integrated melt electrowriting 3D printer
Hoey, David; Kelly, Daniel (2022)Melt electrowriting (MEW) is a high resolution material extrusion based additive manufacturing process with the unique capability to produce micron to sub-micron diameter fibres and control their deposition in three ... -
Human bone marrow stem/stromal cell osteogenesis is regulated via mechanically activated osteocyte-derived extracellular vesicles
O'Driscoll, Lorraine; Hoey, David (2020)Bone formation or regeneration requires the recruitment, proliferation, and osteogenic differentiation of stem/stromal progenitor cells. A potent stimulus driving this process is mechanical loading. Osteocytes are ... -
Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells
Hoey, David (2022)Mechanical stimulation plays in an important role in regulating stem cell differentiation and their release of extracellular vesicles (EVs). In this study, effects of low magnitude hydrostatic pressure (HP) on the chondrogenic ... -
Mechanically stimulated osteocytes promote the proliferation and migration of breast cancer cells via a potential CXCL1/2 mechanism
Hoey, David (2021)Bone represents the most common site for breast cancer metastasis. Bone is a highly dynamic organ that is constantly adapting to its biophysical environment, orchestrated largely by the resident osteocyte network. Osteocytes ... -
Mechanoregulatory role of TRPV4 in prenatal skeletal development
Hoey, David (2023)Biophysical cues are essential for guiding skeletal development, but the mechanisms underlying the mechanical regulation of cartilage and bone formation are unknown. TRPV4 is a mechanically sensitive ion channel involved ... -
Mediating human stem cell behaviour via defined fibrous architectures by melt electrospinning writing.
Hoey, David (2018)The architecture within which cells reside is key to mediating their specific functions within the body. In this study, we use melt electrospinning writing (MEW) to fabricate cell micro-environments with various fibrous ...