Browsing Mechanical, Manufacturing & Biomedical Eng by Author "Buckley, Conor"
Now showing items 1-20 of 37
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Anisotropic Shape-Memory Alginate Scaffolds Functionalized with Either Type I or Type II Collagen for Cartilage Tissue Engineering
Kelly, Daniel; Buckley, Conor (2017) -
Biomechanical studies of feline ventral abdominal wall and celiotomy closure techniques.
Buckley, Conor (2018)Objective: To compare biomechanical properties and mechanism of failure of 3 regions of ventral abdominal wall in cats by using 2 suture materials, 2 suture bite‐to‐stitch intervals (SBSI), and full‐thickness versus ... -
Chondrocyte based Intraoperative Processing Strategies for the Biological Augmentation of a Polyurethane Meniscal Replacement
Buckley, Conor; Kelly, Daniel (2017) -
Combining BMP-6, TGF-β3 and hydrostatic pressure stimulation enhances the functional development of cartilage tissues engineered using human infrapatellar fat pad derived stem cells
Kelly, Daniel; Buckley, Conor (2013)The objective of this study was to identify a combination of growth factors that could be used with hydrostatic pressure (HP) stimulation to enhance the functional development of cartilaginous grafts engineered using human ... -
Consolidating and re-evaluating the human disc nutrient microenvironment
Buckley, Conor; McDonnell, Emily E. (2022)Background: Despite exciting advances in regenerative medicine, cell-based strategies for treating degenerative disc disease remain in their infancy. To maximize the potential for successful clinical translation, a more ... -
Controlled release of transforming growth factor-?3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells.
Kelly, Daniel; Cunniffe, Gr?inne; Buckley, Conor (2014)Abstract: The objective of this study was to develop a scaffold derived from cartilaginous extracellular matrix (ECM) that could be used as a growth factor delivery system to promote chondrogenesis of stem cells. ... -
Cyclic tensile strain can play a role in directing both intramembranous and endochondral ossification of mesenchymal stem cells.
Buckley, Conor; Kelly, Daniel (2017) -
Decellularized grafts with axially aligned channels for peripheral nerve regeneration.
Reilly, Richard; Buckley, Conor (2015) -
The effect of concentration, cooling rate and cell seeding density on the initial mechanical properties of agarose hydrogels.
Buckley, Conor; Robinson, Anthony; Kelly, Daniel (2009)Agarose hydrogels are commonly used for cartilage tissue engineering studies and to provide a three dimensional environment to investigate cellular mechanobiology. Interpreting the results of such studies requires accurate ... -
Effects of Growth Factor Combinations TGFβ3, GDF5 and GDF6 on the Matrix Synthesis of Nucleus Pulposus and Nasoseptal Chondrocyte Self-Assembled Microtissues
Buckley, Conor; McDonnell, Emily E.; Samuel, Shani (2022)There has been significant interest in identifying alternative cell sources and growth factor stimulation to improve matrix synthesis for disc repair. Recent work has identified nasoseptal chondrocytes (NC) as a possible ... -
Engineering of large cartilaginous constructs through the use of microchanneled hydrogels and rotational culture
Kelly, Daniel; Buckley, Conor (2009)The development of functional engineered cartilaginous tissues of sufficient size that can be used clinically to treat large defects remains a major and significant challenge. This study investigated if the introduction ... -
Expansion in the presence of FGF-2 enhances the functional development of cartilaginous tissues engineered using infrapatellar fat pad derived MSCs
Kelly, Daniel; Buckley, Conor (2012)MSCs from non-cartilaginous knee joint tissues such as the infrapatellar fat pad (IFP) and synovium possess significant chondrogenic potential and provide a readily available and clinically feasible source of chondroprogenitor ... -
Functional Properties of Cartilaginous Tissues Engineered From Infrapatellar Fat Pad Derived Mesenchymal Stem Cells.
Kelly, Daniel; Buckley, Conor (2010)Articular cartilage has a poor intrinsic capacity for self-repair. The advent of autologous chondrocyte implantation has provided a feasible method to treat cartilage defects. However, the associated drawbacks with the ... -
Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering
Buckley, Conor; Dunne, Aisling; Kelly, Daniel (2019)Extracellular matrix (ECM)-derived implants hold great promise for tissue repair, but new strategies are required to produce efficiently decellularized scaffolds with the necessary porosity and mechanical properties to ... -
Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells.
Buckley, Conor; Kelly, Daniel; Ahearne, Mark; Rolfe, Rebecca (2012)Hydrostatic pressure (HP) is a key component of the in vivo joint environment and has been shown to enhance chondrogenesis of stem cells. The objective of this study was to investigate the interaction between HP and ...