Interferon-alpha-induced cognitive and affective impairments : contributions of prefrontal cortex and hippocampal formation
Citation:
Sally Barlow, 'Interferon-alpha-induced cognitive and affective impairments : contributions of prefrontal cortex and hippocampal formation', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009, pp 285Download Item:
Abstract:
Interferon-alpha (IFN-a) is a potent antiviral agent useful in the treatment of many malignancies, but most widely used in the treatment of Hepatitis C. However, sinister adverse events appear as a consequence of IFN-a-treatment. Such side effects include fatigue, fever (‘flu-like’ symptoms) and more serious symptoms such as memory impairments, anxiety, depression and suicidal ideation. Symptoms of major depression present in ~40% of the clinical population taking this drug. The mechanisms underlying these side effects remain elusive; this thesis aims to unravel mechanisms underlying these adverse events.
Author: Barlow, Sally
Advisor:
O'Mara, ShaneQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of PsychiatryNote:
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Full text availableKeywords:
Psychology, Ph.D., Ph.D. Trinity College DublinMetadata
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