Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines
Citation:
Henry C.M, Sullivan G.P, Clancy D.M, Afonina I.S, Kulms D, Martin S.J, Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines, Cell Reports, 14, 4, 2016, 708 - 722Download Item:
Abstract:
IL-36 cytokines require proteolytic
processing for activation, but how this is
achieved is unknown. Here, Henry et al.
show that proteases liberated from
activated neutrophils—cathepsin G,
elastase, and proteinase-3—differentially
process and activate all three IL-36 family
members. Therefore, neutrophil-derived
proteases can escalate inflammation
through processing of extracellular
cytokines.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
SFI/14/IA/2622
Author's Homepage:
http://people.tcd.ie/martinsjDescription:
PUBLISHEDCited By :11 Export Date: 6 January 2017
Author: MARTIN, SEAMUS
Type of material:
Journal ArticleCollections
Series/Report no:
Cell Reports14
4
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Full text availableKeywords:
IL-36 cytokinesDOI:
http://dx.doi.org/10.1016/j.celrep.2015.12.072Metadata
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