Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?
Citation:
O'Toole R.F, Shukla S.D, Walters E.H, Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?, Journal of Translational Medicine, 14, 1, 2016Download Item:
art%3A10.1186%2Fs12967-016-1063-x.pdf (PDF) 964.6Kb
Abstract:
Abstract
Expression of the platelet-activating factor receptor is upregulated in the respiratory epithelium of smokers and
chronic obstructive pulmonary disease patients. We have recently determined that increased expression of PAFr cor
-
relates with higher levels of adhesion to human bronchial epithelial cells by non-typable
Haemophilus influenzae
and
Streptococcus pneumoniae
which are major bacterial pathogens in acute exacerbations of COPD. In addition, we found
that a PAFr antagonist decreased the adhesion of both respiratory bacterial pathogens to non-cigarette exposure con
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trol levels. This highlights the possibility that epithelial receptors, that are upregulated in response to cigarette smoke,
could be targeted to specifically block chronic bacterial infections of the lower respiratory tract. In this commentary,
we explore the question of whether adhesion to a temporally-upregulated host receptor is a common event in
chronic bacterial disease, and as such, could represent a putative therapeutic target for blocking infection by respira-
tory and other pathogens.
Author's Homepage:
http://people.tcd.ie/otooler3
Author: O'TOOLE, RONAN
Type of material:
Journal ArticleCollections:
Series/Report no:
Journal of Translational Medicine14
1
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http://dx.doi.org/10.1186/s12967-016-1063-xLicences: